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Agnes Le Saux
Researcher at Curie Institute
Publications - 6
Citations - 284
Agnes Le Saux is an academic researcher from Curie Institute. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 4, co-authored 6 publications receiving 134 citations. Previous affiliations of Agnes Le Saux include PSL Research University & University of Paris.
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Journal ArticleDOI
SPEN integrates transcriptional and epigenetic control of X-inactivation.
François Dossin,Inês Pinheiro,Jan J. Żylicz,Jan J. Żylicz,Julia Roensch,Samuel Collombet,Agnes Le Saux,Tomasz Chelmicki,Mikael Attia,Varun Kapoor,Ye Zhan,Florent Dingli,Damarys Loew,Thomas Mercher,Job Dekker,Job Dekker,Edith Heard +16 more
TL;DR: It is proposed that SPEN acts as a molecular integrator for the initiation of XCI, bridging Xist RNA with the transcription machinery—as well as with nucleosome remodellers and histone deacetylases—at active enhancers and promoters.
Journal ArticleDOI
Molecular basis of CTCF binding polarity in genome folding
Elphège P. Nora,Laura Caccianini,Geoffrey Fudenberg,Kevin So,Vasumathi Kameswaran,Abigail Nagle,Abigail Nagle,Alec Uebersohn,Alec Uebersohn,Bassam Hajj,Agnes Le Saux,Agnes Le Saux,Antoine Coulon,Leonid A. Mirny,Katherine S. Pollard,Katherine S. Pollard,Maxime Dahan,Benoit G. Bruneau +17 more
TL;DR: It is reported that CTCF positions cohesin, but does not control its overall binding dynamics on chromatin, by combining ChIP-seq and single molecule live imaging and using an inducible complementation system.
Journal ArticleDOI
A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary.
Rafael Galupa,Elphège P. Nora,Rebecca Worsley-Hunt,Christel Picard,Chris Gard,Joke Gerarda van Bemmel,Nicolas Servant,Yinxiu Zhan,Yinxiu Zhan,Fatima El Marjou,Colin Johanneau,Patricia Diabangouaya,Agnes Le Saux,Sonia Lameiras,Juliana Pipoli da Fonseca,Friedemann Loos,Joost Gribnau,Sylvain Baulande,Uwe Ohler,Uwe Ohler,Luca Giorgetti,Edith Heard,Edith Heard +22 more
TL;DR: It is discovered that the Xist locus is regulated by sequences in the neighboring TAD, and the promoter of the noncoding RNA Linx (LinxP) acts as a long-range silencer and influences the choice of X chromosome to be inactivated.
Journal ArticleDOI
H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing.
Sjoerd J. D. Tjalsma,Mayako Hori,Yuko Sato,Aurelie Bousard,Akito Ohi,Ana Cláudia Raposo,Julia Roensch,Agnes Le Saux,Jumpei Nogami,Kazumitsu Maehara,Tomoya Kujirai,Tetsuya Handa,Sandra Bagés-Arnal,Yasuyuki Ohkawa,Hitoshi Kurumizaka,Simão Teixeira da Rocha,Jan J. Żylicz,Jan J. Żylicz,Jan J. Żylicz,Hiroshi Kimura,Edith Heard,Edith Heard +21 more
TL;DR: In this article, a genetically encoded, H3K27me3-specific intracellular antibody or H4K20me1-mintbody was developed to follow X chromosome inactivation (XCI) dynamics in living cells.
Posted ContentDOI
Tracking H3K27me3 and H4K20me1 dynamics during XCI reveals similarities in recruitment mechanism
Sjoerd J. D. Tjalsma,Mayako Hori,Yuko Sato,Aurelie Bousard,Akito Ohi,Ana Cláudia Raposo,Julia Roensch,Agnes Le Saux,Jumpei Nogami,Kazumitsu Maehara,Tomoya Kujirai,Yasuyuki Ohkawa,Hitoshi Kurumizaka,Simão Teixeira da Rocha,Jan J. Żylicz,Jan J. Żylicz,Hiroshi Kimura,Edith Heard +17 more
TL;DR: To follow XCI dynamics in living cells, a genetically-encoded, H3K27me3-specific intracellular antibody is developed and by combining it with live-imaging of H4K20me1, the X chromosome and Xist RNA, similarities in the initial accumulation dynamics are uncovered.