A
Anton Goloborodko
Researcher at Massachusetts Institute of Technology
Publications - 60
Citations - 7841
Anton Goloborodko is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 21, co-authored 55 publications receiving 5957 citations. Previous affiliations of Anton Goloborodko include Moscow Institute of Physics and Technology & Russian Academy of Sciences.
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Journal ArticleDOI
Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg,Maxim Imakaev,Carolyn Lu,Anton Goloborodko,Nezar Abdennur,Leonid A. Mirny,Leonid A. Mirny +6 more
TL;DR: This model produces TADs and finer-scale features of Hi-C data because each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops.
Journal ArticleDOI
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Elphège P. Nora,Anton Goloborodko,Anne-Laure Valton,Johan H. Gibcus,Alec Uebersohn,Nezar Abdennur,Job Dekker,Leonid A. Mirny,Benoit G. Bruneau +8 more
TL;DR: The data support that CTCF mediates transcriptional insulator function through enhancer blocking but not as a direct barrier to heterochromatin spreading, and provides new fundamental insights into the rules governing mammalian genome organization.
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Iterative correction of Hi-C data reveals hallmarks of chromosome organization
Maxim Imakaev,Geoffrey Fudenberg,Rachel Patton McCord,Natalia Naumova,Anton Goloborodko,Bryan R. Lajoie,Job Dekker,Leonid A. Mirny,Leonid A. Mirny +8 more
TL;DR: In this article, the authors present a pipeline that integrates a strategy for mapping of sequencing reads and a data-driven method for iterative correction of biases, yielding genome-wide maps of relative contact probabilities.
Journal ArticleDOI
Two independent modes of chromatin organization revealed by cohesin removal
Wibke Schwarzer,Nezar Abdennur,Anton Goloborodko,Aleksandra Pekowska,Geoffrey Fudenberg,Yann Loe-Mie,Nuno A. Fonseca,Wolfgang Huber,Christian H. Haering,Leonid A. Mirny,François Spitz +10 more
TL;DR: It is shown that deletion of the cohesin-loading factor Nipbl in mouse liver leads to a marked reorganization of chromosomal folding, and the disappearance of TADs unmasks a finer compartment structure that accurately reflects the underlying epigenetic landscape.
Journal ArticleDOI
A pathway for mitotic chromosome formation
Johan H. Gibcus,Kumiko Samejima,Anton Goloborodko,Itaru Samejima,Natalia Naumova,Johannes Nuebler,Masato T. Kanemaki,Linfeng Xie,James R. Paulson,William C. Earnshaw,Leonid A. Mirny,Job Dekker +11 more
TL;DR: A pathway of mitotic chromosome folding is described that unifies many previous observations and identifies roles of specific molecular machines, condensin I and II, in these major conformational transitions.