Alejandro Carazo

TL;DR: In this article, the authors provide a complex view on the present knowledge about vitamin A ranging from its sources through its physiological functions to consequences of its deficiency and metabolic fate up to possible pharmacological administration and potential toxicity.

TL;DR: The analogues with a trifluoromethyl group instead of one of the nitro groups maintained a high antimycobacterial activity, which indicates the possibility for further structural optimization of this class of antitubercular agents.

TL;DR: Pregnane X receptor mediates induction of the principal xenobiotic metabolizing enzymes and transporters in the liver and down‐regulation of OCT1 expression by PXR activation is assessed.

TL;DR: Vitamin K is traditionally connected with blood coagulation, since it is needed for the posttranslational modification of 7 proteins involved in this cascade, but it is also involved in the maturation of another 11 or 12 proteins that play different roles, encompassing the modulation of the calcification of connective tissues as discussed by the authors.

TL;DR: Propiconazole and Te affect different hepatotoxicity-relevant cellular targets and, depending on the individual endpoint analyzed, act via similar or dissimilar mechanisms.