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Alejandro J. Cagnoni
Researcher at Instituto de Biología y Medicina Experimental
Publications - 21
Citations - 348
Alejandro J. Cagnoni is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Galectin & Biology. The author has an hindex of 6, co-authored 15 publications receiving 200 citations. Previous affiliations of Alejandro J. Cagnoni include National Scientific and Technical Research Council.
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Journal ArticleDOI
Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer
Alejandro J. Cagnoni,Juan M. Pérez Sáez,Gabriel A. Rabinovich,Gabriel A. Rabinovich,Karina Mariño +4 more
TL;DR: The current status of the discovery and development of chemical lectin inhibitors is reviewed and novel strategies to limit cancer progression by targeting lectin–glycan interactions are discussed.
Journal ArticleDOI
Re-wiring regulatory cell networks in immunity by galectin–glycan interactions
Ada G. Blidner,Santiago P. Méndez-Huergo,Alejandro J. Cagnoni,Gabriel A. Rabinovich,Gabriel A. Rabinovich +4 more
TL;DR: This work focuses on the emerging roles of galectins, a family of highly conserved glycan‐binding proteins in regulating the fate and function of regulatory immune cell populations, both of lymphoid and myeloid origins.
Journal ArticleDOI
Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8+ regulatory T cells.
Alejandro J. Cagnoni,María Laura Giribaldi,Ada G. Blidner,Anabela M. Cutine,Sabrina G. Gatto,Rosa M. Morales,Mariana Salatino,Martín Carlos Abba,Diego O. Croci,Karina Mariño,Gabriel A. Rabinovich +10 more
TL;DR: Cagnoni et al. as mentioned in this paper presented a study of the relationship between the biomedical field and medical field, and the Instituto de Biologia y Medicina Experimental (IBME).
Journal ArticleDOI
Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth.
Fátima Ferragut,Alejandro J. Cagnoni,Lucas L. Colombo,Clara Sanchez Terrero,Carlota Wolfenstein-Todel,María F. Troncoso,Silvia Vanzulli,Gabriel A. Rabinovich,Karina Mariño,María T. Elola +9 more
TL;DR: It is found that silencing of ALCAM in MDA-MB-231 triple negative breast cancer cells decreases cell adhesion and migration onto Gal-8-coated surfaces in a glycan-dependent fashion and cell sialylation controls Gal- 8-mediated cellAdhesion.
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Glycosylation-dependent galectin-receptor interactions promote Chlamydia trachomatis infection.
Agustin Leonardo Lujan,Diego O. Croci,Julián Gambarte Tudela,Antonella Denise Losinno,Alejandro J. Cagnoni,Karina Mariño,María T. Damiani,Gabriel A. Rabinovich +7 more
TL;DR: It is shown that galectin-1 (Gal1), an endogenous lectin widely expressed in female and male genital tracts, promotes Ct infection through glycosylation-dependent mechanisms involving recognition of bacterial glycoproteins and N-glycosylated host cell receptors, and Gal1 enhanced Ct attachment to cervical epithelial cells.