A
Aleksander Hinek
Researcher at University of Toronto
Publications - 108
Citations - 5488
Aleksander Hinek is an academic researcher from University of Toronto. The author has contributed to research in topics: Elastin & Tropoelastin. The author has an hindex of 41, co-authored 101 publications receiving 5135 citations. Previous affiliations of Aleksander Hinek include Hospital for Sick Children.
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Journal ArticleDOI
Signaling Pathways Transduced through the Elastin Receptor Facilitate Proliferation of Arterial Smooth Muscle Cells
TL;DR: It is demonstrated that soluble peptides, elastin degradation products stimulate proliferation of arterial smooth muscle cells and induction of these signals can be abolished by anti-EBP antibody or by galactosugars, which cause shedding of EBP from the cell surface.
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Elastic fibres and vascular structure in hypertension
TL;DR: Current knowledge regarding components of elastic fibres are reviewed and their possible pathomechanistic associations with vascular structural abnormalities and with hypertension development or progression are discussed.
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Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome.
Zsolt Urban,Sheila Riazi,Thomas L. Seidl,Jodi Katahira,Leslie B. Smoot,David Chitayat,Charles D. Boyd,Aleksander Hinek +7 more
TL;DR: It is concluded that insoluble elastin is an important regulator of cellular proliferation and leads to the increased proliferation of arterial SMCs, which results in the formation of multilayer thickening of the tunica media of large arteries and the development of hyperplastic intimal lesions leading to segmental arterial occlusion.
Journal ArticleDOI
Elastin binds to a multifunctional 67-kilodalton peripheral membrane protein
Robert P. Mecham,Aleksander Hinek,Ruth A. Entwistle,David S. Wrenn,Gail L. Griffin,Robert M. Senior +5 more
TL;DR: It is proposed that the 67-, 61-, and 55-kDa proteins constitute an elastin-receptor complex that forms a transmembrane link between the extracellular matrix and the intracellular compartment.
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The 67-kDa Enzymatically Inactive Alternatively Spliced Variant of β-Galactosidase Is Identical to the Elastin/Laminin-binding Protein
TL;DR: The results conclusively identify the 67-kDa splice variant of β-galactosidase as EBP.