W
Willa A. Hsueh
Researcher at Ohio State University
Publications - 262
Citations - 19776
Willa A. Hsueh is an academic researcher from Ohio State University. The author has contributed to research in topics: Insulin resistance & Diabetes mellitus. The author has an hindex of 76, co-authored 254 publications receiving 18588 citations. Previous affiliations of Willa A. Hsueh include UCLA Medical Center & San Francisco General Hospital.
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Journal ArticleDOI
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Sean B. Joseph,Elaine McKilligin,Liming Pei,Michael A. Watson,Alan R. Collins,Bryan A. Laffitte,Mingyi Chen,Grace Noh,Joanne Goodman,Graham N. Hagger,Jonathan Tran,Tim K. Tippin,Xuping Wang,Aldons J. Lusis,Willa A. Hsueh,Ronald E. Law,Jon L. Collins,Timothy M. Willson,Peter Tontonoz +18 more
TL;DR: It is demonstrated here that the nonsteroidal LXR agonist GW3965 has potent antiatherogenic activity in two different murine models, providing direct evidence for an atheroprotective effect of LXRs agonists and support their further evaluation as potential modulators of human cardiovascular disease.
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Minireview: adiposity, inflammation, and atherogenesis.
TL;DR: Greater understanding of adipokine regulation should result in the design of improved treatment strategies to control disease states associated with increase adiposity, an important outcome in view of the growing worldwide epidemic of obesity.
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Obesity, Inflammation, and Cancer
TL;DR: How adipose tissue becomes inflamed in obesity is described, ways these mechanisms impact cancer development are summarized, and their role in four adipose-associated cancers that demonstrate elevated incidence or mortality in obesity are discussed.
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Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.
Ronald E. Law,William P. Meehan,X P Xi,Kristof Graf,D A Wuthrich,William D. Coats,David P. Faxon,Willa A. Hsueh +7 more
TL;DR: Results suggest troglitazone is a potent inhibitor of VSMC proliferation and migration and, thus, may be a useful agent to prevent restenosis and possibly atherosclerosis.
Journal ArticleDOI
Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells
Ronald E. Law,Stephan Goetze,Xiao-Ping Xi,Simon K. Jackson,Yasuko Kawano,Linda L. Demer,Michael C. Fishbein,Woerner P. Meehan,Willa A. Hsueh +8 more
TL;DR: Pharmacological activation of PPARγ expressed in VSMCs inhibits their proliferation and migration, potentially limiting restenosis and atherosclerosis and suggesting these receptors are upregulated during vascular injury.