Alessandra Altomare

TL;DR: The disulphide breaking activity of NAC also explains its mucolytic activity which is due to its effect in reducing heavily cross-linked mucus glycoproteins and free thiols as well as reduced proteins which have important direct antioxidant activity.

TL;DR: A key role for early activation/sensitization of TRPA1 by oxidative stress by-products in producing CIPN is highlighted and prevention strategies for CIPn in patients are suggested through the use of early, short-term treatments with TRPA 1 antagonists.

TL;DR: Treatment with carnosine improves glucose metabolism, albuminuria and pathology in BTBR ob/ob mice, and could be a novel therapeutic strategy to treat patients with DN and/or be used to prevent DN in patients with diabetes.

TL;DR: An update on methods to approach the complex field of lipoxidation along with validation strategies and functional assays illustrated with well-studied lipoxidized proteins or peptides is presented.

TL;DR: Data suggest that acrolein is entrapped in vivo by carnosine although the response to its supplementation is possibly influenced by individual diversities in terms of carnosines dietary intake, metabolism and basal production of reactive carbonyl species.