Alessandra Zicari

TL;DR: The high basal PGE2 levels in OI, a noninflammatory disorder, could be explained by stress-induced release mediated by inducible cyclooxygenase-2-catalyzed pathway, which could be attributed to a direct pharmacological effect since these drugs has been reported to modulate the release of proinflammatory mediators.

TL;DR: It was demonstrated that HMGB1, which is released by damaged cells and tumor cells, upregulates miR-221/222 oncogenic clusters in the two human neuroblastoma derived cell lines, which may lead to the development of novel therapeutic strategies for Neuroblastoma.

TL;DR: The finding of a higher GO biocompatibility compared to the p-SWCNTs in the same cell lines means that GO nanosheets, which are obtained by the electrochemical exfoliation of a graphite-based electrode (carried out in saline solutions or other physiological working media) could represent an eligible nanocarrier for drug delivery, gene transfection and molecular cell imaging tests.

TL;DR: Findings suggest that in the above tissues: 1) the arachidonate lipoxygenase pathway is highly active before labor; 2) LTB4 might play a role in the regulation of PGE2 production.

TL;DR: MIF is generated and released by human fetal membranes at term and MIF mRNA and protein expression and release are modulated by NO, which could be a regulator of MIF production in pregnancy and labor.