A
Alessandro A. Sartori
Researcher at University of Zurich
Publications - 52
Citations - 5007
Alessandro A. Sartori is an academic researcher from University of Zurich. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 27, co-authored 49 publications receiving 4397 citations. Previous affiliations of Alessandro A. Sartori include Academy of Sciences of the Czech Republic & Paul Scherrer Institute.
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Journal ArticleDOI
Human CtIP promotes DNA end resection
Alessandro A. Sartori,Claudia Lukas,Julia Coates,Martin Mistrik,Shuang Fu,Jiri Bartek,Richard Baer,Jiri Lukas,Stephen P. Jackson +8 more
TL;DR: These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination.
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RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
J. Ross Chapman,Patricia Barral,Jean-Baptiste Vannier,Valerie Borel,Martin Steger,Antonia Tomás-Loba,Alessandro A. Sartori,Ian R. Adams,Facundo D. Batista,Simon J. Boulton +9 more
TL;DR: Rif1−/− mice are severely compromised for 53BP1-dependent class switch recombination (CSR) and fusion of dysfunctional telomeres and deletion of Rif1 suppresses toxic nonhomologous end joining (NHEJ) induced by PARP inhibition in Brca1-deficient cells.
Journal ArticleDOI
CDK targets Sae2 to control DNA-end resection and homologous recombination.
Pablo Huertas,Felipe Cortés-Ledesma,Alessandro A. Sartori,Alessandro A. Sartori,Andrés Aguilera,Stephen P. Jackson +5 more
TL;DR: This work establishes that cell-cycle control of DSB resection in Saccharomyces cerevisiae results from the phosphorylation by CDK of an evolutionarily conserved motif in the Sae2 protein, and shows that mutating Ser’267 of Sae 2 to a non-phosphorylatable residue causes phenotypes comparable to those of a sae2Δ null mutant.
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Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents
Katja Kratz,Barbara Schöpf,Svenja Kaden,Ataman Sendoel,Ralf Eberhard,Claudio Lademann,Elda Cannavo,Alessandro A. Sartori,Michael O. Hengartner,Josef Jiricny,Josef Jiricny +10 more
TL;DR: The link of KIAA1018 to the FA pathway is further strengthened by its recruitment to DNA damage through interaction of its UBZ domain with monoubiquitylated FANCD2, and it is proposed to name KIAa1018 FAN CD2-associated nuclease, FAN1.
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Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Isabella M. Toller,Kai J. Neelsen,Martin Steger,Mara L. Hartung,Michael O. Hottiger,Manuel Stucki,Behnam Kalali,Markus Gerhard,Alessandro A. Sartori,Massimo Lopes,Anne Müller +10 more
TL;DR: It is concluded that DNA damage followed by potentially imprecise repair is consistent with the carcinogenic properties of H. pylori and with its mutagenic properties in vitro and in vivo and may contribute to the genetic instability and frequent chromosomal aberrations that are a hallmark of gastric cancer.