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Alessandro Protti
Researcher at Humanitas University
Publications - 111
Citations - 4682
Alessandro Protti is an academic researcher from Humanitas University. The author has contributed to research in topics: Mechanical ventilation & Lactic acidosis. The author has an hindex of 29, co-authored 100 publications receiving 3101 citations. Previous affiliations of Alessandro Protti include University College London & University of Milan.
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Journal ArticleDOI
Ventilator-related causes of lung injury: the mechanical power.
Luciano Gattinoni,Tommaso Tonetti,Massimo Cressoni,P. Cadringher,Peter Herrmann,Onnen Moerer,Alessandro Protti,Miriam Gotti,Chiara Chiurazzi,Eleonora Carlesso,Davide Chiumello,Michael Quintel +11 more
TL;DR: The mechanical power equation may help estimate the contribution of the different ventilator-related causes of lung injury and of their variations.
Journal ArticleDOI
Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study.
Giacomo Grasselli,Giacomo Grasselli,Tommaso Tonetti,Alessandro Protti,Thomas Langer,Massimo Girardis,Giacomo Bellani,John G. Laffey,Gianpaolo Carrafiello,Gianpaolo Carrafiello,Luca Carsana,Chiara Rizzuto,Alberto Zanella,Alberto Zanella,Vittorio Scaravilli,Giacinto Pizzilli,Domenico Luca Grieco,Letizia Di Meglio,Gennaro De Pascale,Ezio Lanza,Francesco Monteduro,Maurizio Zompatori,Claudia Filippini,Franco Locatelli,Maurizio Cecconi,Roberto Fumagalli,Stefano Nava,Jean Louis Vincent,Massimo Antonelli,Arthur S. Slutsky,Antonio Pesenti,Antonio Pesenti,V. Marco Ranieri,Alfredo Lissoni,N Rossi,Amedeo Guzzardella,Carlo Valsecchi,Fabiana Madotto,Francesca Bevilacqua,Marco Di Laudo,Lorenzo Querci,Carmen Seccafico +41 more
TL;DR: Patients with COVID-19-associated ARDS have a form of injury that, in many aspects, is similar to that of those with ARDS unrelated to CO VID-19, who have a reduction in respiratory system compliance together with increased D-dimer concentrations have high mortality rates.
Journal ArticleDOI
Lung stress and strain during mechanical ventilation: any safe threshold?
Alessandro Protti,Massimo Cressoni,Alessandro Santini,Thomas Langer,Cristina Mietto,D. Febres,Monica Chierichetti,Silvia Coppola,G. Conte,Stefano Gatti,O. Leopardi,Serge Masson,Luciano Lombardi,M. Lazzerini,E. Rampoldi,Paolo Cadringher,Luciano Gattinoni +16 more
TL;DR: In this paper, the authors identify a strain-stress threshold (if any) above which ventilator-induced lung damage can occur, defined as net increase in lung weight.
Journal ArticleDOI
Hospital surge capacity in a tertiary emergency referral centre during the COVID-19 outbreak in Italy.
L. Carenzo,E. Costantini,Massimiliano Greco,F. L. Barra,V. Rendiniello,M. Mainetti,R. Bui,Alberto Zanella,Giacomo Grasselli,M. Lagioia,Alessandro Protti,Maurizio Cecconi +11 more
TL;DR: A dedicated task force identified a response plan, which included establishment of dedicated, cohorted intensive care units for COVID‐19–positive patients and design of appropriate procedures for pre‐triage, diagnosis and isolation of suspected and confirmed cases.
Journal ArticleDOI
Ventilator-induced lung injury: the anatomical and physiological framework.
TL;DR: It is suggested that stress at rupture is only rarely reached and that high tidal volume induces ventilator-induced lung injury by augmenting the pressure heterogeneity at the interface between open and constantly closed units.