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Alessandro Rufini
Researcher at University of Leicester
Publications - 40
Citations - 3024
Alessandro Rufini is an academic researcher from University of Leicester. The author has contributed to research in topics: Cancer & Apoptosis. The author has an hindex of 21, co-authored 38 publications receiving 2657 citations. Previous affiliations of Alessandro Rufini include University of Rome Tor Vergata & Medical Research Council.
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Journal ArticleDOI
Senescence and aging: the critical roles of p53
TL;DR: This review focuses on the recent advances on the contribution of p53 to cellular senescence and its implication for cancer therapy, and describes p53-mediated regulation of several physiological pathways that could mediate its role in both senescences and aging.
Journal ArticleDOI
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
Richard Tomasini,Katsuya Tsuchihara,Margareta Wilhelm,Masashi Fujitani,Alessandro Rufini,Carol C. Cheung,Fatima Khan,Annick Itie-Youten,Andrew Wakeham,Ming-Sound Tsao,Juan L. Iovanna,Jeremy A. Squire,Igor Jurisica,David L. Kaplan,Gerry Melino,Andrea Jurisicova,Tak W. Mak +16 more
TL;DR: TAp73 isoforms exert tumor-suppressive functions and indicate an emerging role for Trp73 in the maintenance of genomic stability, as well as hippocampal dysgenesis.
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Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice
Eleonora Candi,Alessandro Rufini,Alessandro Terrinoni,David Dinsdale,Marco Ranalli,Andrea Paradisi,V De Laurenzi,Luigi Giusto Spagnoli,M V Catani,Safaa M. Ramadan,Richard A. Knight,Gerry Melino,Gerry Melino +12 more
TL;DR: The two p63 isoforms appear to play distinct cooperative roles in epidermal formation, as double TAp63α/ΔNp 63α complementation showed greater patches of differentiated skin and at the ultrastructural level, there was clear reformation of a distinct basal membrane and hemidesmosomes.
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Isoform-specific p73 knockout mice reveal a novel role for ΔNp73 in the DNA damage response pathway
Margareta Wilhelm,Alessandro Rufini,Monica K. Wetzel,Katsuya Tsuchihara,Satoshi Inoue,Richard Tomasini,Annick Itie-Youten,Andrew Wakeham,Marie Arsenian-Henriksson,Gerry Melino,David L. Kaplan,Freda D. Miller,Tak W. Mak +12 more
TL;DR: It is found that DeltaNp73 localizes directly to the site of DNA damage, can interact with the DNA damage sensor protein 53BP1, and inhibits ATM activation and subsequent p53 phosphorylation, which may explain why human tumors with high levels of DeltaN p73 expression show enhanced resistance to chemotherapy.
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Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice
Hong Cai,Edwina N. Scott,Abeer O. Kholghi,Catherine Andreadi,Alessandro Rufini,Ankur Karmokar,Robert G. Britton,Emma Horner-Glister,Peter Greaves,Dhafer Jawad,Mark I. James,Lynne M. Howells,Ted J. Ognibene,Michael A. Malfatti,Christopher E. Goldring,Neil R. Kitteringham,Joanne Walsh,Maria Viskaduraki,Kevin West,Andrew S. Miller,David Hemingway,William P. Steward,Andreas J. Gescher,Karen Brown +23 more
TL;DR: It is shown that a low rather than a high dose of resveratrol prevents tumor growth in mice and alters metabolic pathways in human tissues and suggests that it's time for a revision in development strategies for preventative dietary agents.