Joanne Walsh

TL;DR: It is demonstrated that under chronic exposure, the sensitivity of the hepatocytes drastically increased and toxicity of a set of hepatotoxins was detected at clinically relevant concentrations, and the PHH spheroid system constitutes a versatile and promising in vitro system to study liver function, liver diseases, drug targets and long-term DILI.

TL;DR: It is shown here for the first time, that the enzyme ATP-citrate lyase, responsible for acetyl-CoA production, is negatively regulated by NRF2, suggesting that Nrf2 is a major regulator of cellular lipid disposition in the liver.

TL;DR: It is shown that a low rather than a high dose of resveratrol prevents tumor growth in mice and alters metabolic pathways in human tissues and suggests that it's time for a revision in development strategies for preventative dietary agents.

TL;DR: The key factors and pathways which underlie the loss of hepatic phenotype in vitro, particularly those driving the large-scale and selective remodelling of the mitochondrial and metabolic proteomes are reported, to facilitate further development of simple and complex hepatic culture systems.

TL;DR: It is suggested that Nrf2 activity is required to counter rises in intracellular reactive oxygen species and to regulate pathways that control DC co-stimulatory receptor expression.