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Alessandro Vergara
Researcher at University of Naples Federico II
Publications - 120
Citations - 2286
Alessandro Vergara is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Raman spectroscopy & Protein crystallization. The author has an hindex of 27, co-authored 117 publications receiving 2010 citations. Previous affiliations of Alessandro Vergara include Massachusetts Institute of Technology & Lawrence Livermore National Laboratory.
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Journal ArticleDOI
An Overview of Biological Macromolecule Crystallization
TL;DR: The general aspects of protein crystallization are introduced, conventional and innovative crystallization methods are summarized and the new strategies utilized to improve the success rate of experiments and increase crystal diffraction quality are focused on.
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Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis.
Antonello Merlino,Irene Russo Krauss,Immacolata Castellano,Emmanuele De Vendittis,Bianca Rossi,Maria Conte,Alessandro Vergara,Filomena Sica +7 more
TL;DR: The crystal structure of a cold-adapted Fe-SOD from the Antarctic eubacterium Pseudoalteromonas haloplanktis and that of its complex with sodium azide are presented to underline how fine structural modifications can alter enzyme flexibility and/or stability without compromising the overall structure of typical rigid enzymes, such as SODs.
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The mode of action of anticancer gold-based drugs: a structural perspective
Luigi Messori,Federica Scaletti,Lara Massai,Maria Agostina Cinellu,Chiara Gabbiani,Alessandro Vergara,Antonello Merlino +6 more
TL;DR: The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography to provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.
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Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu.
Alessandro Vergara,Gerardino D'Errico,Daniela Montesarchio,Gaetano Mangiapia,Luigi Paduano,Antonello Merlino +5 more
TL;DR: The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy and provide clear evidence on the mechanism ofAziRu-protein adduct formation and of ligand exchange in the crystal state.
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Biological interactions of biocompatible and water-dispersed MoS 2 nanosheets with bacteria and human cells.
Jasneet Kaur,Manjot Singh,Carmela Dell'Aversana,Rosaria Benedetti,Paola Giardina,Manuela Rossi,Mohammadhassan Valadan,Alessandro Vergara,Anna Cutarelli,Angela Michela Immacolata Montone,Lucia Altucci,Federica Corrado,Angela Nebbioso,Carlo Altucci +13 more
TL;DR: High-quality, few-layered and defect-free MoS2 nanosheets, exfoliated and dispersed in pure water, stabilized up to three weeks are produced and cytotoxic effect induced in the tumor cell lines is absent in the normal cells in the tested conditions.