Paul Meraner

TL;DR: It is found that both flaviviruses require the endoplasmic reticulum membrane complex for their early stages of infection, and insights are provided into the role of the EMC in flavivirus replication.

TL;DR: FZDs are established as physiologically relevant receptors for TcdB in the colonic epithelium by carrying out CRISPR–Cas9-mediated genome-wide screens and identifying the members of the Wnt receptor frizzled family (FzDs) as TCDB receptors.

TL;DR: ITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle and can prevent Zika-virus-induced cell death, suggesting that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.

TL;DR: It is found that HCMV infection of epithelial cells is blocked by a synthetic OR14I1 peptide and inhibitors of adenylate cyclase and protein kinase A (PKA) signaling, which reveal previously unappreciated targets for the development of vaccines and antiviral therapies.

TL;DR: The results strongly support a model according to which IFITM3 accumulation at the sites of virus fusion is a prerequisite for its antiviral activity and that this protein traps viral fusion at a hemifusion stage by preventing the formation of fusion pores.