J
Ji Miao
Researcher at Boston Children's Hospital
Publications - 46
Citations - 3300
Ji Miao is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 21, co-authored 35 publications receiving 2614 citations. Previous affiliations of Ji Miao include Harvard University & University of Illinois at Urbana–Champaign.
Papers
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Journal ArticleDOI
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Bhaskar Ponugoti,Dong-Hyun Kim,Zhen Xiao,Zachary Smith,Ji Miao,Mengwei Zang,Shwu Yuan Wu,Cheng Ming Chiang,Timothy D. Veenstra,Jongsook Kim Kemper +9 more
TL;DR: It is reported that SREBP-1c, a key lipogenic activator, is an in vivo target of SIRT1, and acetylation levels were elevated in diet-induced obese mice, and hepatic overexpression of SIRC1 or treatment with resveratrol daily for 1 week decreased acetylated SRE BP- 1c levels with beneficial functional outcomes.
Journal ArticleDOI
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
Jongsook Kim Kemper,Zhen Xiao,Bhaskar Ponugoti,Ji Miao,Sungsoon Fang,Deepthi Kanamaluru,Stephanie Tsang,Shwu Yuan Wu,Cheng Ming Chiang,Timothy D. Veenstra +9 more
TL;DR: It is reported that FXR is a target of SIRT1, a deacetylase that mediates nutritional and hormonal modulation of hepatic metabolism that reduces acetylated FXR levels and may be a promising therapeutic agents for metabolic disorders.
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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
Ji Miao,Alisha V. Ling,Praveen V. Manthena,Mary E Gearing,Mark J. Graham,Rosanne M. Crooke,Kevin Croce,Ryan M. Esquejo,Clary B. Clish,David Vicent,Sudha B. Biddinger +10 more
TL;DR: In this article, the authors identify the enzyme flavin-containing monooxygenase 3 (Fmo3) to be a target of insulin and show that FMO3 is suppressed by insulin in vitro, increased in obese/insulin resistant male mice and increased in overweight/inulin resistant humans.
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A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via MicroRNA-34a inhibition
Ji Young Lee,Amruta Padhye,Abhilasha Sharma,Guisheng Song,Ji Miao,Yin-Yuan Mo,Li Wang,Jongsook Kim Kemper +7 more
TL;DR: It is reported that the nuclear bile acid receptor farnesoid X receptor (FXR) inhibits microRNA-34a (miR-34A) in the liver, which results in a positive regulation of SIRT1 levels, which may be useful for treating diseases of aging and cancer.
Journal ArticleDOI
Differential Regulation of Rat and Human CYP7A1 by the Nuclear Oxysterol Receptor Liver X Receptor-α
TL;DR: It is demonstrated that in primary cultures of human hepatocytes, activation of LXRalpha has the opposite effect, repressing CYP7A1 expression, and that SHP is regulated directly by LXR alpha through a DNA response element that overlaps with the previously characterized bile acid response element.