Alex Rovira

TL;DR: No cause-effect relationship has been demonstrated in patients between brain gadolinium exposure and clinical consequences specific to neurological toxicity, as confirmed by preclinical animal and human (MR imaging and autopsy) studies.

TL;DR: Two cases of atypical acute Schmörl's nodes are described, one benign, the other on a tumoral vertebra, showing a decreased vertebral T1 signal and a slightly increased T2 signal that are indistinguishable from tumoral disease or inflammatory lesions.

TL;DR: The infratentorial lesion criterion is responsible for the lower specificity of Barkhof criteria in CISB, as compared with specificity in other CIS, in which all 4 criteria demonstrate dissemination in space.

TL;DR: The results provide further evidence for increased bihemispheric contributions to motor control in patients with MS relative to healthy controls and suggest that multicentre fMRI studies of FC changes are possible, and provide a potential imaging biomarker for use in experimental therapeutic studies directed at enhancing adaptive plasticity in the disease.

TL;DR: At the patient level, whole-brain and white matter volume changes in the first year of interferon β therapy are predictive of subsequent clinical evolution under treatment.