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Alexander A. Ishchenko
Researcher at Université Paris-Saclay
Publications - 93
Citations - 2600
Alexander A. Ishchenko is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: DNA glycosylase & Base excision repair. The author has an hindex of 28, co-authored 83 publications receiving 2251 citations. Previous affiliations of Alexander A. Ishchenko include Russian Academy of Sciences & Institut Gustave Roussy.
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The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway
TL;DR: It is reported that Ape1, the major apurinic/apyrimidinic endonuclease in human cells, is the damage- specific endonUClease involved in NIR, and the kinetic constants indicate that APe1-catalysed NIR activity is highly efficient.
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The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells
Anastasia Zlatanou,Emmanuelle Despras,Tirzah Braz-Petta,Imenne Boubakour-Azzouz,Caroline Pouvelle,Grant S. Stewart,Satoshi Nakajima,Akira Yasui,Alexander A. Ishchenko,Patricia Kannouche +9 more
TL;DR: It is shown that in response to oxidative stress, PCNA becomes transiently monoubiquitinated in an S phase- and USP1-independent manner and Polη interacts with mUb-PCNA at sites of oxidative DNA damage via its PCNA-binding and ubiquitin-binding motifs.
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Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
Ibtissam Talhaoui,N. A. Lebedeva,Gabriella Zarkovic,Christine Saint-Pierre,M. M. Kutuzov,Maria V. Sukhanova,Bakhyt T. Matkarimov,Didier Gasparutto,Murat Saparbaev,Olga I. Lavrik,Alexander A. Ishchenko +10 more
TL;DR: In in vitro biochemical experiments, it is found that the mammalian PARP1 and PARP2 proteins can directly ADP-ribosylate the termini of DNA oligonucleotides.
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Human DNA polymerase iota protects cells against oxidative stress.
Tirzah Braz Petta,Satoshi Nakajima,Anastasia Zlatanou,Emmanuelle Despras,Sophie Couvé-Privat,Alexander A. Ishchenko,Alain Sarasin,Akira Yasui,Patricia Kannouche +8 more
TL;DR: The data reveal a novel role of human polι in protecting cells from oxidative damage and green fluorescent protein‐tagged polι accumulates at the sites of oxidative DNA damage in living cells.
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Characterization of DNA ADP-ribosyltransferase Activities of PARP2 and PARP3: New Insights Into DNA ADP-ribosylation
Gabriella Zarkovic,Ekaterina A. Belousova,Ibtissam Talhaoui,Christine Saint-Pierre,M. M. Kutuzov,Bakhyt T. Matkarimov,Denis Biard,Didier Gasparutto,Olga I. Lavrik,Alexander A. Ishchenko +9 more
TL;DR: It is shown that mammalian PARP2 and PARP3 can PARylate and mono(ADP-ribosyl)ate (MARylate), respectively, 5′- and 3′-terminal phosphate residues at double- and single-strand break termini of a DNA molecule containing multiple strand breaks.