A
Alexander Bohla
Researcher at Ludwig Maximilian University of Munich
Publications - 21
Citations - 1182
Alexander Bohla is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Cystic fibrosis & Neutrophil extracellular traps. The author has an hindex of 15, co-authored 21 publications receiving 1053 citations. Previous affiliations of Alexander Bohla include University of Münster & University of Regensburg.
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Journal ArticleDOI
CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
Veronica Marcos,Zhe Zhou,Aö Yildirim,Alexander Bohla,Andreas Hector,Andreas Hector,Ljubomir Vitkov,Ljubomir Vitkov,Eva-Maria Wiedenbauer,Wolf Dietrich Krautgartner,Walter Stoiber,Bernd H. Belohradsky,Nikolaus Rieber,Michael Kormann,Michael Kormann,Barbara Koller,Adelbert A. Roscher,Dirk Roos,Matthias Griese,Oliver Eickelberg,Gerd Döring,Marcus A. Mall,Dominik Hartl,Dominik Hartl +23 more
TL;DR: Pulmonary blockade of CXCR2 by intra-airway delivery of small-molecule antagonists inhibited NET formation and improved lung function in vivo without affecting neutrophil recruitment, proteolytic activity or antibacterial host defense.
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Activation of the WNT/β-catenin pathway attenuates experimental emphysema.
Nikolaus Kneidinger,Ali Önder Yildirim,Jens Callegari,Shinji Takenaka,Maria Magdalena Stein,Rio Dumitrascu,Alexander Bohla,Ken R. Bracke,Rory E. Morty,Guy Brusselle,Ralph T. Schermuly,Oliver Eickelberg,Melanie Königshoff +12 more
TL;DR: Preventive and therapeutic, WNT/β-catenin activation by lithium chloride attenuated experimental emphysema, as assessed by decreased airspace enlargement, improved lung function, reduced collagen content, and elevated expression of alveolar epithelial cell markers is indicated.
Journal ArticleDOI
Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
Simone Schleede,Felix G. Meinel,Martin Bech,Martin Bech,Julia Herzen,Klaus Achterhold,Guillaume Potdevin,Andreas Malecki,Silvia Adam-Neumair,Sven F. Thieme,Fabian Bamberg,Konstantin Nikolaou,Alexander Bohla,Ali Oe. Yildirim,Roderick J. Loewen,Martin Gifford,Ronald D. Ruth,Oliver Eickelberg,Maximilian F. Reiser,Franz Pfeiffer +19 more
TL;DR: In this paper, the authors used grating-based dark-field images of emphysematous vs. healthy lung tissue to monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, which is related to small-angle scattering in the sample.
Journal ArticleDOI
Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner.
Andre Yaroshenko,Felix G. Meinel,Martin Bech,Arne Tapfer,Astrid Velroyen,Simone Schleede,Sigrid Auweter,Alexander Bohla,Ali Oe. Yildirim,Konstantin Nikolaou,Fabian Bamberg,Oliver Eickelberg,Maximilian F. Reiser,Franz Pfeiffer +13 more
TL;DR: X-ray dark-field scatter images of murine lungs obtained with a preclinical scanner can be used in the diagnosis of pulmonary emphysema.
Journal ArticleDOI
Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction
Veronica Marcos,Zhe Zhou-Suckow,Aö Yildirim,Alexander Bohla,Andreas Hector,Ljubomir Vitkov,Wolf Dietrich Krautgartner,Walter Stoiber,Matthias Griese,Oliver Eickelberg,Marcus A. Mall,Dominik Hartl +11 more
TL;DR: It is demonstrated that neutrophilic inflammation in CF airways is associated with abundant free DNA characteristic for NETosis, and suggested that free DNA may be implicated in lung function decline in patients with CF.