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Adelbert A. Roscher
Researcher at Ludwig Maximilian University of Munich
Publications - 133
Citations - 6921
Adelbert A. Roscher is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Gene & Peroxisome. The author has an hindex of 46, co-authored 132 publications receiving 6532 citations. Previous affiliations of Adelbert A. Roscher include Boston Children's Hospital & University of California, San Diego.
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Journal ArticleDOI
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
M. Hrabe de Angelis,Heinrich Flaswinkel,Helmut Fuchs,Birgit Rathkolb,Dian Soewarto,S. Marschall,Stephan Heffner,Walter Pargent,K. Wuensch,M. Jung,André Reis,Thomas Richter,Francesca Alessandrini,Thilo Jakob,Edith Fuchs,Hubert Kolb,Elisabeth Kremmer,K. Schaeble,B. Rollinski,Adelbert A. Roscher,Christoph Peters,Thomas Meitinger,T. M. Strom,Thomas Steckler,Florian Holsboer,Thomas Klopstock,F. Gekeler,C. Schindewolf,Thomas S. Jung,Karen B. Avraham,Heidrun Behrendt,Johannes Ring,Andreas Zimmer,Klaus Schughart,Klaus Pfeffer,Eckhard Wolf,Rudi Balling +36 more
TL;DR: In screening over 14,000 mice for a large number of clinically relevant parameters, 182 mouse mutants are recovered and this mutagenesis screen leads to a significant increase in the number of mouse models available to the scientific community.
Journal ArticleDOI
Predicting phenotype in steroid 21-hydroxylase deficiency? Comprehensive genotyping in 155 unrelated, well defined patients from southern Germany.
TL;DR: A good genotype-phenotype relationship is shown in patients with either the severest or the mildest mutations, and a considerable degree of divergence is observed within mutation groups of intermediate severity.
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Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease.
Dominik Hartl,Dominik Hartl,Philipp Latzin,Peter L. Hordijk,Veronica Marcos,Carsten Rudolph,Markus Woischnik,Susanne Krauss-Etschmann,Barbara Koller,Dietrich Reinhardt,Adelbert A. Roscher,Dirk Roos,Matthias Griese +12 more
TL;DR: It is shown that IL-8 promotes bacterial killing by neutrophils through CX CR1 but not CXCR2, which represents a new pathophysiologic mechanism in cystic fibrosis and other chronic lung diseases.
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Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS)
Gerhard Liebisch,Wolfgang Drobnik,Markus Reil,Barbara Trümbach,Ralf Arnecke,Bernhard Olgemöller,Adelbert A. Roscher,Gerd Schmitz +7 more
TL;DR: The developed electrospray tandem mass spectrometry (ESI-MS/MS) technique is capable of quantifying different CER species from crude cellular lipid extracts and enables accurate and rapid analysis of CER from small samples without prior separation steps, thus providing a useful tool for signal transduction research.
Journal ArticleDOI
Tetrahydrobiopterin as an Alternative Treatment for Mild Phenylketonuria
Ania C. Muntau,Wulf Röschinger,Matthias Habich,Hans Demmelmair,Björn Hoffmann,Christian P. Sommerhoff,Adelbert A. Roscher +6 more
TL;DR: Tetrahydrobiopterin responsiveness is common in patients with mild hyperphenylalaninemia phenotypes and cannot consistently be predicted on the basis of genotype, particularly in compound heterozygotes.