A
Alexander D. Bershadsky
Researcher at National University of Singapore
Publications - 160
Citations - 21403
Alexander D. Bershadsky is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cytoskeleton & Actin cytoskeleton. The author has an hindex of 60, co-authored 153 publications receiving 19939 citations. Previous affiliations of Alexander D. Bershadsky include Medical Research Council & Academy of Medical Sciences, United Kingdom.
Papers
More filters
Journal ArticleDOI
Environmental sensing through focal adhesions
TL;DR: The mechanisms of such environmental sensing are discussed, based on the finely tuned crosstalk between the assembly of one type of integrin-based adhesion complex, namely focal adhesions, and the forces that are at work in the associated cytoskeletal network owing to actin polymerization and actomyosin contraction.
Journal ArticleDOI
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
Nathalie Q. Balaban,Ulrich S. Schwarz,Daniel Riveline,Polina Goichberg,Gila Tzur,Ilana Sabanay,Diana Mahalu,Samuel A. Safran,Alexander D. Bershadsky,Lia Addadi,Benjamin Geiger +10 more
TL;DR: The results put clear constraints on the possible molecular mechanisms for the mechanosensory response of focal adhesions to applied force.
Journal ArticleDOI
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
TL;DR: This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
Journal ArticleDOI
Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism
Daniel Riveline,Daniel Riveline,Eli Zamir,Nathalie Q. Balaban,Ulrich S. Schwarz,Toshimasa Ishizaki,Shuh Narumiya,Zvi Kam,Benjamin Geiger,Alexander D. Bershadsky +9 more
TL;DR: Experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force, and that external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts.
Journal ArticleDOI
Adhesion-dependent cell mechanosensitivity.
TL;DR: This review discusses the structure-function relationships of focal adhesions and the possible mode of action of the putative mechanosensor associated with them, the general phenomenon of mechanosensitivity, and the approaches used to measure local forces at adhesion sites.