M
Massimiliano Caiazzo
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 25
Citations - 2180
Massimiliano Caiazzo is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Dopaminergic & Reprogramming. The author has an hindex of 13, co-authored 19 publications receiving 1886 citations. Previous affiliations of Massimiliano Caiazzo include Utrecht University & Vita-Salute San Raffaele University.
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Journal ArticleDOI
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Massimiliano Caiazzo,Maria Teresa Dell’Anno,Elena Dvoretskova,Dejan Lazarevic,Dejan Lazarevic,Stefano Taverna,Damiana Leo,Tatyana D. Sotnikova,Andrea Menegon,Paola Roncaglia,Giorgia Colciago,Giovanni Russo,Piero Carninci,Gianni Pezzoli,Raul R. Gainetdinov,Stefano Gustincich,Stefano Gustincich,Alexander Dityatev,Vania Broccoli +18 more
TL;DR: A minimal set of three transcription factors were able to elicit dopaminergic neuronal conversion in prenatal and adult fibroblasts from healthy donors and Parkinson’s disease patients and might have significant implications for understanding critical processes for neuronal development, in vitro disease modelling and cell replacement therapies.
Journal ArticleDOI
Defined three-dimensional microenvironments boost induction of pluripotency
Massimiliano Caiazzo,Yuya Okawa,Adrian Ranga,Alessandra Piersigilli,Yoji Tabata,Matthias P. Lutolf +5 more
TL;DR: It is found that the physical cell confinement imposed by the 3D microenvironment boosts reprogramming through an accelerated mesenchymal-to-epithelial transition and increased epigenetic remodelling and it is concluded that 3Dmicroenvironmental signals act synergistically with reprograming transcription factors to increase somatic plasticity.
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Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors
Massimiliano Caiazzo,Serena Giannelli,Pierluigi Valente,Gabriele Lignani,Annamaria Carissimo,Alessandro Sessa,Gaia Colasante,Rosa Bartolomeo,Luca Massimino,Stefano Ferroni,Carmine Settembre,Fabio Benfenati,Fabio Benfenati,Vania Broccoli +13 more
TL;DR: Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors and it is proved both by gene-expression profiling and functional tests that iAstrocytes are comparable to native brain astroCytes.
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Neural tube morphogenesis in synthetic 3D microenvironments
Adrian Ranga,Mehmet Girgin,Andrea Meinhardt,Dominic Eberle,Massimiliano Caiazzo,Elly M. Tanaka,Matthias P. Lutolf +6 more
TL;DR: Modular synthetic 3D matrices are used to show that early neural morphogenesis can be precisely controlled by the extracellular microenvironment and demonstrate how key ECM parameters are involved in specifying cytoskeleton-mediated symmetry-breaking events that ultimately lead to neural tube-like patterning along the dorsal–ventral (DV) axis.
Journal ArticleDOI
Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.
Gaia Colasante,Gabriele Lignani,Alicia Rubio,Lucian Medrihan,Latefa Yekhlef,Alessandro Sessa,Luca Massimino,Serena Giannelli,Silvio Sacchetti,Massimiliano Caiazzo,Damiana Leo,Dimitra Alexopoulou,Maria Teresa Dell’Anno,Ernesto Ciabatti,Marta Orlando,Michèle Studer,Michèle Studer,Andreas Dahl,Raul R. Gainetdinov,Raul R. Gainetdinov,Stefano Taverna,Fabio Benfenati,Vania Broccoli +22 more
TL;DR: Five factors that convert mouse fibroblasts into induced GABAergic INs possessing molecular signatures of telencephalic INs suggest that iGABA-INs have potential for disease modeling and cell-based therapeutic approaches to neurological disorders.