Alexander G. Markov

TL;DR: In accordance with Repi the most proximal of the small intestinal segments, duodenum exhibited highest expression of “tightening” claudins and lowest expression of claudin-2, -7, and -12, compared to jejunum and ileum, which correspond to the specific role of theduodenum as the first segment facing the acidic gastric content.

TL;DR: Further evidence needs to be gathered on whether modulation of the renin angiotensin system would be advantageous due to upregulation of Mas activation or harmful due to the concomitant ACE-2 receptor upregulation in the acute management of COVID-19.

TL;DR: In this paper, the authors provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19 and post-pandemic.

TL;DR: A critical view on the current understanding of tight junction protein co‐localization within strands is provided and how tissue specific differences of claudin functions could be dependent on their specific partners for barrier formation is analyzed.

TL;DR: Claudin‐2 represents the prototype of a paracellular, channel‐forming, tight junction protein responsible for specific transfer of solutes across the epithelium without entering the cells, and Claudin‐8, another barrier builder, was demonstrated to be regulated by Na+ uptake in surface epithelial cells of human colon.