COVID-19 and metabolic disease: mechanisms and clinical management.
Charlotte Steenblock,Peter Schwarz,Barbara Ludwig,Andreas Linkermann,Paul Zimmet,Konstantin Y. Kulebyakin,Vsevolod A. Tkachuk,Alexander G. Markov,Hendrik Lehnert,Martin Hrabě de Angelis,Hannes Rietzsch,Roman N. Rodionov,Kamlesh Khunti,David Hopkins,Andreas L. Birkenfeld,Bernhard O. Boehm,Richard I. G. Holt,Jay S. Skyler,J. Hans DeVries,Eric Renard,Robert H. Eckel,K. George M.M. Alberti,Bruno Geloneze,Juliana C.N. Chan,Jean Claude Mbanya,Henry Chijioke Onyegbutulem,Ambady Ramachandran,Abdul Basit,Mohamed Hassanein,Gavin A. Bewick,Giatgen A. Spinas,Felix Beuschlein,Rüdiger Landgraf,Francesco Rubino,Geltrude Mingrone,Stefan R. Bornstein +35 more
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TLDR
In this paper, the authors provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19 and post-pandemic.About:
This article is published in The Lancet Diabetes & Endocrinology.The article was published on 2021-10-04 and is currently open access. It has received 119 citations till now. The article focuses on the topics: Diabetes mellitus & Disease.read more
Citations
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Risks and burdens of incident diabetes in long COVID: a cohort study
TL;DR: In this paper , the authors examined the post-acute risk and burden of incident diabetes in people who survived the first 30 days of SARS-CoV-2 infection.
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Risks and burdens of incident diabetes in long COVID: a cohort study
Yan Xie,Ziyad Al-Aly +1 more
TL;DR: Increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during the same period and had not contracted SARS-CoV-2, and a historical control group from a pre-pandemic era are reported.
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The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus
TL;DR: In this paper , the authors characterized the K18-hACE2 mouse model expressing human (h)ACE2 in mice, controlled by the human keratin 18 (K18) promoter in the epithelia, including airway epithelial cells where SARS-CoV-2 infections typically start.
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Sexual dimorphism in COVID-19: potential clinical and public health implications
TL;DR: Zhou et al. as mentioned in this paper discussed how sex hormones, comorbidities, and the sex chromosome complement influence these mechanisms in the context of COVID-19 and suggested that sex differences could be considered in future pandemic surveillance and treatment of patients with COVID19 to help to achieve better disease stratification and improved outcomes.
Journal ArticleDOI
Sexual dimorphism in COVID-19: potential clinical and public health implications
Nicole Bechmann,Andreas Barthel,Andreas Schedl,Stephan Herzig,Zsuzsanna T. Varga,Catherine Gebhard,Manuel Mayr,Constanze Hantel,Felix Beuschlein,Christian Wolfrum,Nikolaos Perakakis,Lucilla Poston,Cynthia L. Andoniadou,Richard C.M. Siow,Raul R. Gainetdinov,Arad Dotan,Yehuda Shoenfeld,Geltrude Mingrone,Stefan R. Bornstein +18 more
TL;DR: It is argued that sexual dimorphism has potential implications for disease treatment, public health measures, and follow-up of patients predisposed to the development of long COVID.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
TL;DR: It is demonstrating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination, and it is shown that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of Sars- coV- 2 S and SARS S bind with similar affinities to human ACE2, correlating with the efficient spread of SATS among humans.
Journal ArticleDOI
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor.
Jun Lan,Jiwan Ge,Jinfang Yu,Sisi Shan,Huan Zhou,Shilong Fan,Qi Zhang,Xuanling Shi,Qisheng Wang,Linqi Zhang,Xinquan Wang +10 more
TL;DR: High-resolution crystal structures of the receptor-binding domain of the spike protein of SARS-CoV-2 and SARS -CoV in complex with ACE2 provide insights into the binding mode of these coronaviruses and highlight essential ACE2-interacting residues.
Journal ArticleDOI
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Annemarie B Docherty,Ewen M Harrison,Christopher A Green,Hayley E Hardwick,Riinu Pius,Lisa Norman,Karl A Holden,Jonathan M. Read,Frank Dondelinger,Gail Carson,Laura Merson,James A. Lee,Daniel Plotkin,Louise Sigfrid,Sophie Halpin,Clare Jackson,Carrol Gamble,Peter Horby,Jonathan S. Nguyen-Van-Tam,Antonia Ho,Clark D Russell,Jake Dunning,Jake Dunning,Peter J. M. Openshaw,J Kenneth Baillie,Malcolm G Semple +25 more
TL;DR: In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity, and the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks is shown.