G
Gavin A. Bewick
Researcher at King's College London
Publications - 59
Citations - 2614
Gavin A. Bewick is an academic researcher from King's College London. The author has contributed to research in topics: Appetite & Energy homeostasis. The author has an hindex of 23, co-authored 50 publications receiving 2009 citations. Previous affiliations of Gavin A. Bewick include Hammersmith Hospital & Imperial College London.
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Journal ArticleDOI
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents.
Arianna Psichas,Michelle L. Sleeth,Kevin Murphy,Lucy Brooks,Gavin A. Bewick,Aylin C. Hanyaloglu,M. A. Ghatei,S.R. Bloom,Gary Frost +8 more
TL;DR: It is demonstrated that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo, and colonic propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice.
Journal ArticleDOI
Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
Gavin A. Bewick,James Gardiner,Waljit S. Dhillo,Aysha Kent,N. E. White,Zoe Webster,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TL;DR: The data suggest that postembryonic partial loss of AgRP/NPY neurons leads to a lean, hypophagic phenotype in mice with targeted deletion of either NPY or AgRP or both.
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The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro.
Attilio Pingitore,Edward S. Chambers,Thomas G. Hill,Inmaculada Ruz Maldonado,Bo Liu,Gavin A. Bewick,Douglas J. Morrison,Tom Preston,Gareth A. Wallis,Catriona Tedford,Ramón Castañera González,Guo Cai Huang,Pratik Choudhary,Gary Frost,Shanta J. Persaud +14 more
TL;DR: The effects of increasing colonic delivery of the SCFA propionate on β‐cell function in humans and the direct effects of propionates on isolated human islets in vitro are evaluated.
Journal ArticleDOI
Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety.
Lucy Brooks,Alexander Viardot,Anastasia Tsakmaki,Emilie Stolarczyk,Jane K. Howard,Patrice D. Cani,Amandine Everard,Michelle L. Sleeth,Arianna Psichas,Jelena Anastasovskaj,Jimmy D. Bell,Kim S. Bell-Anderson,Charles R. Mackay,Charles R. Mackay,Mohammad A. Ghatei,Stephen R. Bloom,Gary Frost,Gavin A. Bewick,Gavin A. Bewick +18 more
TL;DR: It is demonstrated that FFAR2 is predominantly involved in regulating the effects of fermentable carbohydrate on metabolism and does so, in part, by enhancing PYY cell density and release, which highlights the potential for targeting enteroendocrine cell differentiation to treat obesity.
Journal ArticleDOI
The role of the gut/brain axis in modulating food intake.
TL;DR: This review gives an overview of the main gut hormones implicated in the regulation of food intake, and provides novel targets for the pharmacological treatment of obesity.