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Alexander J. Westermann
Researcher at University of Würzburg
Publications - 47
Citations - 3173
Alexander J. Westermann is an academic researcher from University of Würzburg. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 17, co-authored 38 publications receiving 2421 citations. Previous affiliations of Alexander J. Westermann include University of Tübingen & University of California, Berkeley.
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Single-cell RNA-seq: advances and future challenges
TL;DR: An overview of the biological questions single-cell RNA-seq has been used to address, the major findings obtained from such studies, and current challenges and expected future developments in this booming field are provided.
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Dual RNA-seq of pathogen and host
TL;DR: The feasibility of taking transcriptomics one step further by performing 'dual RNA-seq', in which gene expression changes in both the pathogen and the host are analysed simultaneously, is assessed.
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Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions
Alexander J. Westermann,Konrad U. Förstner,Fabian Amman,Fabian Amman,Lars Barquist,Yanjie Chao,Leon N. Schulte,Lydia Müller,Richard Reinhardt,Peter F. Stadler,Jörg Vogel +10 more
TL;DR: A generic ‘dual RNA-seq’ approach is used to profile RNA expression simultaneously in pathogen and host during Salmonella enterica serovar Typhimurium infection and reveal the molecular impact of bacterial riboregulators.
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Salmonella persisters undermine host immune defenses during antibiotic treatment
Daphne A.C. Stapels,Peter W. S. Hill,Alexander J. Westermann,Robert A. Fisher,Teresa L. M. Thurston,Antoine-Emmanuel Saliba,Isabelle Blommestein,Jörg Vogel,Sophie Helaine +8 more
TL;DR: It is shown that Salmonella persisters arising during macrophage infection maintain a metabolically active state, which may confer an advantage to the pathogen during relapse once antibiotic pressure is relieved.
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Resolving host-pathogen interactions by dual RNA-seq
TL;DR: The knowledge gained from these recent studies are used to suggest experimental and computational guidelines for the design of future dual RNA-seq studies, and a review of prospective applications of the technique is discussed.