A
Alexander Koch
Researcher at Hannover Medical School
Publications - 2
Citations - 170
Alexander Koch is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Neointima & Smoothened. The author has an hindex of 2, co-authored 2 publications receiving 140 citations.
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Journal ArticleDOI
Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.
Jan Marcus Daniel,Daniela Penzkofer,Rebecca Teske,Jochen Dutzmann,Alexander Koch,Wiebke Bielenberg,Angelika Bonauer,Reinier A. Boon,Ariane Fischer,Johann Bauersachs,Eva van Rooij,Stefanie Dimmeler,Daniel Sedding +12 more
TL;DR: It is indicated that inhibition of endothelial miR-92a attenuates neointimal lesion formation by accelerating re-endothelialization and thus represents a putative novel mechanism to enhance the functional recovery following vascular injury.
Journal ArticleDOI
Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation.
Jochen Dutzmann,Alexander Koch,Simona Weisheit,Kristina Sonnenschein,L Korte,Marco Haertlé,Thomas Thum,Thomas Thum,Johann Bauersachs,Daniel Sedding,J M Daniel +10 more
TL;DR: It is shown that proliferation of vascular smooth muscle cells (SMC) after wire-induced injury in C57BL/6 mice is preceded by proliferation of adventitial fibroblasts, and SMO-dependent Shh signalling is identified as a specific process for the activation of advential fibro Blasts.