A
Ariane Fischer
Researcher at Goethe University Frankfurt
Publications - 47
Citations - 5633
Ariane Fischer is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelium & Gene silencing. The author has an hindex of 22, co-authored 44 publications receiving 4727 citations. Previous affiliations of Ariane Fischer include Medical University of Vienna.
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Journal ArticleDOI
MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
Angelika Bonauer,Guillaume Carmona,Masayoshi Iwasaki,Marina Mione,Masamichi Koyanagi,Ariane Fischer,Jana Burchfield,Henrik Fox,Carmen Doebele,Kisho Ohtani,Emmanouil Chavakis,Michael Potente,Marc Tjwa,Carmen Urbich,Andreas M. Zeiher,Stefanie Dimmeler +15 more
TL;DR: It is shown that themiR-17~92 cluster is highly expressed in human endothelial cells and that miR-92a, a component of this cluster, controls the growth of new blood vessels (angiogenesis) and may serve as a valuable therapeutic target in the setting of ischemic disease.
Journal ArticleDOI
Circulating MicroRNAs in Patients With Coronary Artery Disease
Stephan Fichtlscherer,Salvatore De Rosa,Henrik Fox,Thomas Schwietz,Ariane Fischer,Christoph Liebetrau,Michael Weber,Christian W. Hamm,Tino Röxe,Marga Muller-Ardogan,Angelika Bonauer,Andreas M. Zeiher,Stefanie Dimmeler +12 more
TL;DR: Circulating levels of vascular and inflammation-associated microRNAs are significantly downregulated in patients with coronary artery disease.
Journal ArticleDOI
MicroRNA-34a regulates cardiac ageing and function
Reinier A. Boon,Kazuma Iekushi,Stefanie Lechner,Timon Seeger,Ariane Fischer,Susanne Heydt,David Kaluza,Karine Tréguer,Guillaume Carmona,Angelika Bonauer,Anton J.G. Horrevoets,Nathalie Didier,Zenawit Girmatsion,Peter Biliczki,Joachim R. Ehrlich,Hugo A. Katus,Oliver Müller,Michael Potente,Michael Potente,Andreas M. Zeiher,Heiko Hermeking,Stefanie Dimmeler +21 more
TL;DR: Age-induced expression of miR-34a and inhibition of its target PNUTS is identified as a key mechanism that regulates cardiac contractile function during ageing and after acute myocardial infarction, by inducing DNA damage responses and telomere attrition.
Journal ArticleDOI
Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.
Carmen Doebele,Angelika Bonauer,Ariane Fischer,Alexander Scholz,Yvonne Reiss,Carmen Urbich,Wolf-Karsten Hofmann,Andreas M. Zeiher,Stefanie Dimmeler +8 more
TL;DR: It is shown that miR-17/20 exhibit a cell-intrinsic antiangiogenic activity in endothelial cells, indicating a context-dependent regulation of angiogenesis by miR/20 in vivo.
Journal ArticleDOI
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
Reinier A. Boon,Timon Seeger,Susanne Heydt,Ariane Fischer,Eduard Hergenreider,Anton J.G. Horrevoets,Manlio Vinciguerra,Nadia Rosenthal,Sergio Sciacca,Michele Pilato,Paula M. van Heijningen,Jeroen Essers,Ralf P. Brandes,Andreas M. Zeiher,Stefanie Dimmeler +14 more
TL;DR: In this paper, the authors identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies, including aneurysm formation.