A
Alexander Leunig
Researcher at Ludwig Maximilian University of Munich
Publications - 13
Citations - 631
Alexander Leunig is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Immune system & Immunology. The author has an hindex of 5, co-authored 10 publications receiving 267 citations. Previous affiliations of Alexander Leunig include Columbia University.
Papers
More filters
Journal ArticleDOI
Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy.
Leo Nicolai,Alexander Leunig,Sophia Brambs,Rainer Kaiser,Tobias Weinberger,Michael Weigand,Maximilian Muenchhoff,Johannes C. Hellmuth,Stephan Ledderose,Heiko Schulz,Clemens Scherer,Martina Rudelius,Michael Zoller,Dominik Höchter,Oliver T. Keppler,Daniel Teupser,Bernhard Zwißler,Michael von Bergwelt-Baildon,Stefan Kääb,Steffen Massberg,Kami Pekayvaz,Konstantin Stark +21 more
TL;DR: Evidence is provided that organ involvement and prothrombotic features in COVID-19 are linked by immunothrombosis, and data point to immunothROMbotic dysregulation as a key marker of disease severity in CO VID-19.
Journal ArticleDOI
Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia
Leo Nicolai,Alexander Leunig,Sophia Brambs,Rainer Kaiser,Markus Joppich,Marie-Louise Hoffknecht,Christoph Gold,Anouk Engel,Vivien Polewka,Maximilian Muenchhoff,Johannes C. Hellmuth,Adrian Ruhle,Stephan Ledderose,Tobias Weinberger,Heiko Schulz,Clemens Scherer,Martina Rudelius,Michael Zoller,Oliver T. Keppler,Bernhard Zwißler,Michael von Bergwelt-Baildon,Stefan Kääb,Ralf Zimmer,Roman D. Bülow,Saskia von Stillfried,Peter Boor,Steffen Massberg,Kami Pekayvaz,Konstantin Stark +28 more
TL;DR: It is sought to study whether immunothrombosis is a pathognomonic factor in COVID‐19 or a general feature of (viral) pneumonia, as well as to better understand its upstream regulation.
Journal ArticleDOI
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Rainer Kaiser,Alexander Leunig,Kami Pekayvaz,Oliver Popp,Markus Joppich,Vivien Polewka,Raphael Escaig,Afra Anjum,Marie-Louise Hoffknecht,Christoph Gold,Sophia Brambs,Anouk Engel,Sven Stockhausen,Viktoria Knottenberg,Anna Titova,Mohamed Haji,Clemens Scherer,Maximilian Muenchhoff,Johannes C. Hellmuth,Kathrin Saar,Benjamin Schubert,Anne Hilgendorff,Christian Schulz,Stefan Kääb,Ralf Zimmer,Norbert Hubner,Steffen Massberg,Philipp Mertins,Leo Nicolai,Konstantin Stark +29 more
TL;DR: In this article, the authors identify a reinforcing loop of both systemic and neutrophil intrinsic IL-8 (CXCL8/IL-8) dysregulation, which initiates and perpetuates neutrophin-driven immunopathology.
Journal ArticleDOI
Vascular surveillance by haptotactic blood platelets in inflammation and infection
Leo Nicolai,Karin Schiefelbein,Silvia Lipsky,Alexander Leunig,Marie Hoffknecht,Kami Pekayvaz,Ben Raude,Charlotte Marx,Andreas Ehrlich,Joachim Pircher,Zhe Zhang,Inas Saleh,Anna Kristina Marel,Achim Löf,Tobias Petzold,Michael Lorenz,Konstantin Stark,Robert Pick,Gerhild Rosenberger,Ludwig T. Weckbach,Bernd Uhl,Sheng Xia,Christoph A. Reichel,Barbara Walzog,Christian Schulz,Vanessa Zheden,Markus Bender,Rong Li,Steffen Massberg,Florian Gaertner +29 more
TL;DR: Arp2/3-dependent lamellipodia formation is identified as a prominent morphological feature of immune-responsive platelets that interferes with haptotactic repositioning of platelets to microlesions, thus impairing vascular sealing and provoking inflammatory microbleeding.
Posted ContentDOI
Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration
Leo Nicolai,Alexander Leunig,Kami Pekayvaz,Afra Anjum,Eva Riedlinger,Luke Eivers,Marie-Louise Hoffknecht,Dario Rossaro,Raphael Escaig,Rainer Kaiser,Vivien Polewka,Anna Titova,Karsten Spiekermann,Matteo Iannacone,Konstantin Stark,Steffen Massberg +15 more
TL;DR: In this paper, the platelet-adenovirus aggregate formation and platelet activation was shown to trigger a B-cell response with the emergence of circulating antibodies binding to platelets.