K
Konstantin Stark
Researcher at Ludwig Maximilian University of Munich
Publications - 70
Citations - 4478
Konstantin Stark is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Platelet. The author has an hindex of 20, co-authored 52 publications receiving 2868 citations. Previous affiliations of Konstantin Stark include Alliance University & Technische Universität München.
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Journal ArticleDOI
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
Marie-Luise von Brühl,Konstantin Stark,Alexander Steinhart,Sue Chandraratne,Ildiko Konrad,Michael Lorenz,Alexander G. Khandoga,Anca Tirniceriu,Raffaele Coletti,Maria Köllnberger,Robert A. Byrne,Iina Laitinen,Axel Walch,Alexander Brill,Susanne Pfeiler,Davit Manukyan,Siegmund Braun,Philipp S. Lange,Julia Riegger,Jerry Ware,Annekathrin Eckart,Selgai Haidari,Martina Rudelius,Christian Schulz,Katrin Echtler,Volker Brinkmann,Markus Schwaiger,Klaus T. Preissner,Denisa D. Wagner,Nigel Mackman,Bernd Engelmann,Steffen Massberg +31 more
TL;DR: Deep vein thrombosis initiation is mediated by cross talk between monocytes, neutrophils, and platelets.
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Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy.
Leo Nicolai,Alexander Leunig,Sophia Brambs,Rainer Kaiser,Tobias Weinberger,Michael Weigand,Maximilian Muenchhoff,Johannes C. Hellmuth,Stephan Ledderose,Heiko Schulz,Clemens Scherer,Martina Rudelius,Michael Zoller,Dominik Höchter,Oliver T. Keppler,Daniel Teupser,Bernhard Zwißler,Michael von Bergwelt-Baildon,Stefan Kääb,Steffen Massberg,Kami Pekayvaz,Konstantin Stark +21 more
TL;DR: Evidence is provided that organ involvement and prothrombotic features in COVID-19 are linked by immunothrombosis, and data point to immunothROMbotic dysregulation as a key marker of disease severity in CO VID-19.
Journal ArticleDOI
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
Konstantin Stark,Annekathrin Eckart,Selgai Haidari,Anca Tirniceriu,Michael Lorenz,Marie-Luise von Brühl,Florian Gärtner,Alexander G. Khandoga,Kyle R. Legate,Robert Pless,Ingrid Hepper,Kirsten Lauber,Barbara Walzog,Steffen Massberg +13 more
TL;DR: The results identify a previously unknown role for NG2+ pericytes as an active component of innate immune responses, which supports the immunosurveillance and effector function of extravasated neutrophils and macrophages.
Journal ArticleDOI
Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.
Florian Gaertner,Zerkah Ahmad,Gerhild Rosenberger,Shuxia Fan,Leo Nicolai,Benjamin Busch,Goekce Yavuz,Manja Luckner,Hellen Ishikawa-Ankerhold,Roman Hennel,Alexandre P. Benechet,Michael Lorenz,Sue Chandraratne,Irene Schubert,Sebastian Helmer,Bianca Striednig,Konstantin Stark,Marek Janko,Ralph T. Böttcher,Admar Verschoor,Catherine Léon,Christian Gachet,Thomas Gudermann,Michael Mederos y Schnitzler,Zachary Pincus,Matteo Iannacone,Rainer Haas,Gerhard Wanner,Kirsten Lauber,Michael Sixt,Steffen Massberg +30 more
TL;DR: It is shown that adherent platelets use adhesion receptors to mechanically probe the adhesive substrate in their local microenvironment and are assigned a central role in innate immune responses and identified as potential targets to dampen inflammatory tissue damage in clinical scenarios of severe systemic infection.
Journal ArticleDOI
Interplay between inflammation and thrombosis in cardiovascular pathology.
TL;DR: In this paper, the synergy between inflammation and thrombosis is discussed, and the huge potential of anti-inflammatory strategies to target cardiovascular pathologies is highlighted, with the aim of covering therapeutic gaps in cardiovascular diseases.