A
Alexander Makarov
Researcher at Thermo Fisher Scientific
Publications - 370
Citations - 17035
Alexander Makarov is an academic researcher from Thermo Fisher Scientific. The author has contributed to research in topics: Mass spectrometry & Orbitrap. The author has an hindex of 47, co-authored 318 publications receiving 15119 citations. Previous affiliations of Alexander Makarov include Moscow Institute of Physics and Technology & Purdue University.
Papers
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Journal ArticleDOI
Parts per Million Mass Accuracy on an Orbitrap Mass Spectrometer via Lock Mass Injection into a C-trap
Jesper V. Olsen,Jesper V. Olsen,Lyris M. F. de Godoy,Guoqing Li,Guoqing Li,Boris Macek,Peter Mortensen,Reinhold Pesch,Alexander Makarov,Oliver Lange,Stevan Horning,Matthias Mann,Matthias Mann +12 more
TL;DR: This work demonstrates sub-ppm mass accuracy on a linear ion trap coupled via a radio frequency-only storage trap to the orbitrap mass spectrometer (LTQ Orbitrap), and introduces a variable mass tolerance to improve certainty of peptide and small molecule identification.
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The Orbitrap: a new mass spectrometer
TL;DR: The Orbitrap as mentioned in this paper is a mass analyzer based on an electrospray ionization source (ESI) with an outer barrel-like electrode, coaxial with the inner spindlelike electrode and mass/charge values measured from the frequency of harmonic ion oscillations along the axis of the electric field, undergone by the orbitally trapped ions.
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Electrostatic Axially Harmonic Orbital Trapping: A High-Performance Technique of Mass Analysis
TL;DR: This work describes a new type of mass analyzer which employs trapping in an electrostatic field and demonstrates high-mass resolution up to 150,000 for ions produced by laser ablation, along with high-energy acceptance and wide mass range.
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Higher-energy C-trap dissociation for peptide modification analysis.
TL;DR: Immonium ions generated via HCD pinpoint modifications such as phosphotyrosine with very high confidence are generated via higher-energy C-trap dissociation (HCD) and this work shows that an added octopole collision cell facilitates de novo sequencing.
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Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer
Annette Michalski,Eugen Damoc,Jan Peter Hauschild,Oliver Lange,Andreas Wieghaus,Alexander Makarov,Nagarjuna Nagaraj,Juergen Cox,Matthias Mann,Stevan Horning +9 more
TL;DR: High performance in a robust benchtop format together with the ability to perform complex multiplexed scan modes make the Q Exactive an exciting new instrument for the proteomics and general analytical communities.