Alexander Quaas

TL;DR: increasing matrix stiffness promotes proliferation and chemotherapeutic resistance, whereas a soft environment induces reversible cellular dormancy and stem cell characteristics in HCC, which has implications for both the treatment of primary HCC and the prevention of tumor outgrowth from disseminated tumor cells.

TL;DR: Analysis of HBV RNA transcripts showed that impaired virion productivity in HBeAg-negative individuals was due to lower steady-state levels of pregenomic RNA produced per cccDNA, which can arise without emergence of H beAg variants and without affecting HBsAg production.

TL;DR: It is concluded that esophageal adenocarcinomas belong to those cancer types with relevant frequency high-level Her-2 gene amplification clinical trials or individual case studies investigating the response of metastatic HER-2-positive esophagal cancers to Herceptin® should be undertaken.

TL;DR: Infliximab may be considered as rescue therapy in patients with difficult-to-treat autoimmune hepatitis, albeit treatment may be associated with infectious complications.

TL;DR: The frequency and function of circulating Treg cells is not impaired inAIH, and analysis of FOXP3+ Treg in liver histology revealed that the intrahepatic Treg frequency was higher in AIH patients than in NASH patients and correlated with the inflammatory activity of the liver.