Guido Sauter

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Until other methods achieve similar test accuracy, reproducibility, and predictive value, it is suggested FISH as the primary Her-2 testing modality for women with breast cancer who are candidates for HER-2-targeted therapies.

TL;DR: In 175 women who had received adjuvant tamoxifen monotherapy, survival was significantly longer forWomen with cancer with ESR1 amplification than for women with estrogen receptor–expressing cancers without ESR2 amplification.

TL;DR: The data strongly support the notion that Ep-CAM is a prime target for immunotherapies in major human malignancies because the most common human cancers show a low frequency of Ep- CAM-negative tumours, a high frequency of epithelial cell adhesion molecule expression on cells of a given tumour, and for most cancers, an insignificant influence of tumour staging, grading and histology.

TL;DR: Data from a validation cohort of > 10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.