S
Sieghart Sopper
Researcher at Innsbruck Medical University
Publications - 147
Citations - 4715
Sieghart Sopper is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Simian immunodeficiency virus & Immune system. The author has an hindex of 33, co-authored 132 publications receiving 3440 citations. Previous affiliations of Sieghart Sopper include University of Würzburg & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Thomas P. Brouwer,Douglas B. Johnson,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula Ericsson-Gonzalez,Pornpimol Charoentong,Pornpimol Charoentong,Justin M. Balko,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +25 more
TL;DR: QuanTIseq as discussed by the authors is a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, which is extensively validated in blood and tumor samples using simulated, flow cytometry, and immunohistochemistry data.
Posted ContentDOI
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
Francesca Finotello,Clemens Mayer,Christina Plattner,Gerhard Laschober,Dietmar Rieder,Hubert Hackl,Anne Krogsdam,Zuzana Loncova,Wilfried Posch,Doris Wilflingseder,Sieghart Sopper,Marieke E. Ijsselsteijn,Douglas B. Johnson,Yaomin Xu,Yu Wang,Melinda E. Sanders,Monica V. Estrada,Paula I. Ericsson-Gonzalez,Justin M. Balko,Noel F C C de Miranda,Zlatko Trajanoski +20 more
TL;DR: QuanTIseq, a deconvolution method that quantifies the densities of ten immune cell types from bulk RNA sequencing data and tissue imaging data, is developed and used to show how kinase inhibitors modulate the immune contexture and suggest that it might have predictive value for immunotherapy.
Journal ArticleDOI
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Igor Theurl,Ingo Hilgendorf,Ingo Hilgendorf,Manfred Nairz,Piotr Tymoszuk,David Haschka,Malte Asshoff,Shun He,Louisa M.S. Gerhardt,Tobias A. W. Holderried,Markus Seifert,Sieghart Sopper,Ashley M. Fenn,Atsushi Anzai,Sara Rattik,Cameron S. McAlpine,Milan Theurl,Peter Wieghofer,Yoshiko Iwamoto,Georg F. Weber,Nina K. Harder,Benjamin G. Chousterman,Tara Arvedson,Mary McKee,Fudi Wang,Oliver M D Lutz,Emanuele Rezoagli,Jodie L. Babitt,Lorenzo Berra,Marco Prinz,Matthias Nahrendorf,Guenter Weiss,Ralph Weissleder,Herbert Y. Lin,Filip K. Swirski +34 more
TL;DR: The liver is identified as the primary organ that supports rapid erythrocyte removal and iron recycling, and a mechanism by which the body adapts to fluctuations in ery throatcyte integrity is uncovered.
Journal ArticleDOI
Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
Kathrin Eller,Alexander H. Kirsch,Anna Maria Wolf,Sieghart Sopper,Andrea Tagwerker,Ursula Stanzl,Dominik Wolf,Wolfgang Patsch,Alexander R. Rosenkranz,Philipp Eller +9 more
TL;DR: Data suggest a potential therapeutic value of Tregs to improve insulin resistance and end organ damage in type 2 diabetes by limiting the proinflammatory milieu.
Journal ArticleDOI
Parkinsonism in HIV dementia
TL;DR: This short review discusses alterations in the nigrostriatal dopaminergic system during early and late immunodeficiency virus infection and the common clinical and biochemical features shared by HIV dementia and Parkinson's disease.