A
Alexander Roller
Researcher at University of Vienna
Publications - 144
Citations - 3463
Alexander Roller is an academic researcher from University of Vienna. The author has contributed to research in topics: Ruthenium & Ligand. The author has an hindex of 29, co-authored 144 publications receiving 2818 citations.
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Journal ArticleDOI
Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation
Christian R. Kowol,Robert Trondl,Petra Heffeter,Vladimir B. Arion,Michael A. Jakupec,Alexander Roller,Markus Galanski,Walter Berger,Bernhard K. Keppler +8 more
TL;DR: The first metal complexes of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine) were synthesized and all ligands and complexes were tested for their in vitro antiproliferative activity in two human cancer cell lines, and structure-activity relationships were established.
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Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide Reductase
Christian R. Kowol,Roland Berger,Rene Eichinger,Alexander Roller,Michael A. Jakupec,Peter Schmidt,Vladimir B. Arion,Bernhard K. Keppler +7 more
TL;DR: The capacity of ligand 1 and its Ga( III) and Fe(III) complexes to destroy the tyrosyl radical of the presumed target ribonucleotide reductase is reported.
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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
Wolfgang Kandioller,Evelyn Balsano,Samuel M. Meier,Ute Jungwirth,Simone Göschl,Alexander Roller,Michael A. Jakupec,Walter Berger,Bernhard K. Keppler,Christian G. Hartinger +9 more
TL;DR: Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
Maria V. Babak,Maria V. Babak,Samuel M. Meier,Kilian Huber,Jóhannes Reynisson,Anton A. Legin,Michael A. Jakupec,Alexander Roller,Alexey Stukalov,Manuela Gridling,Keiryn L. Bennett,Jacques Colinge,Walter Berger,Paul J. Dyson,Giulio Superti-Furga,Bernhard K. Keppler,Christian G. Hartinger +16 more
TL;DR: In this paper, the authors employed a chemical proteomic approach to identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7phosphaadamantane (RAPTA).
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A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines
Werner Ginzinger,Gerhard Mühlgassner,Vladimir B. Arion,Michael A. Jakupec,Alexander Roller,Markus Galanski,Michael R. Reithofer,Walter Berger,Bernhard K. Keppler +8 more
TL;DR: complexation with osmium of quinoxalinone derivatives with benzimidazole or benzothiazole results in a more consistent increase in cytotoxicity than complexation with ruthenium, whereas cell cycle effects are only moderate.