M
Maria V. Babak
Researcher at City University of Hong Kong
Publications - 53
Citations - 1540
Maria V. Babak is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 16, co-authored 38 publications receiving 1038 citations. Previous affiliations of Maria V. Babak include University of Auckland & university of lille.
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Journal ArticleDOI
The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
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Development of anticancer agents: wizardry with osmium.
TL;DR: This review highlights recent advances in the development of osmium anticancer drug candidates and discusses their cellular mechanisms of action.
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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
Maria V. Babak,Maria V. Babak,Samuel M. Meier,Kilian Huber,Jóhannes Reynisson,Anton A. Legin,Michael A. Jakupec,Alexander Roller,Alexey Stukalov,Manuela Gridling,Keiryn L. Bennett,Jacques Colinge,Walter Berger,Paul J. Dyson,Giulio Superti-Furga,Bernhard K. Keppler,Christian G. Hartinger +16 more
TL;DR: In this paper, the authors employed a chemical proteomic approach to identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7phosphaadamantane (RAPTA).
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New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
Kateryna Ohui,Eleonora Afanasenko,Felix Bacher,Rachel Lim Xue Ting,Ayesha Zafar,Núria Blanco-Cabra,Eduard Torrents,Orsolya Dömötör,Nóra V. May,Denisa Darvasiová,Éva A. Enyedy,Ana Popović-Bijelić,Jóhannes Reynisson,Peter Rapta,Maria V. Babak,Giorgia Pastorin,Vladimir B. Arion +16 more
TL;DR: Six morpholine-(iso)thiosemicarbazone hybrids HL1–HL6 and their Cu(II) complexes with good-to-moderate solubility and stability in water were synthesized and characterized and displayed higher antiproliferative activity in cancer cells than triapine.
Journal ArticleDOI
Dual-Targeting Dual-Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity.
Maria V. Babak,Yang Zhi,Bertrand Czarny,Tan Boon Toh,Lissa Hooi,Edward Kai-Hua Chow,Wee Han Ang,Dan Gibson,Giorgia Pastorin +8 more
TL;DR: The authors' PtIV system showed excellent activity in vitro and in vivo, characterized by a cytotoxicity in a low micromolar range and complete tumor remission, respectively.