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Yun Chau Long
Researcher at Karolinska Institutet
Publications - 27
Citations - 2649
Yun Chau Long is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Skeletal muscle & Protein kinase A. The author has an hindex of 22, co-authored 27 publications receiving 2477 citations. Previous affiliations of Yun Chau Long include University Health System & Eli Lilly and Company.
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Journal ArticleDOI
AMP-activated protein kinase signaling in metabolic regulation.
Yun Chau Long,Juleen R. Zierath +1 more
TL;DR: AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism that stimulates glucose uptake and lipid oxidation to produce energy, while turning off energy-consuming processes including glucose and lipid production to restore energy balance.
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AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
Jonas T. Treebak,Stephan Glund,Atul S. Deshmukh,Ditte Kjærsgaard Klein,Yun Chau Long,Thomas E. Jensen,Sebastian Beck Jørgensen,Benoit Viollet,Leif Andersson,Dietbert Neumann,Theo Wallimann,Erik A. Richter,Alexander V. Chibalin,Juleen R. Zierath,Jørgen F. P. Wojtaszewski +14 more
TL;DR: It is shown that AICAR increases AMPK, acetyl-CoA carboxylase, and AS160 phosphorylation by insulin-independent mechanisms in isolated skeletal muscle and implicate AS160 as a downstream target of AMPK.
Journal ArticleDOI
Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance
Alexander V. Chibalin,Ying Leng,Elaine Vieira,Anna Krook,Marie Björnholm,Yun Chau Long,Olga Kotova,Zhihui Zhong,Fumio Sakane,Tatiana L. Steiler,Carolina Nylén,Jianjun Wang,Markku Laakso,Matthew K. Topham,Matthew K. Topham,Marc Gilbert,Harriet Wallberg-Henriksson,Juleen R. Zierath +17 more
TL;DR: A previously unrecognized role for DGKdelta is revealed in contributing to hyperglycemia-induced peripheral insulin resistance and thereby exacerbating the severity of type 2 diabetes.
Journal ArticleDOI
Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle
Stephan Glund,Atul S. Deshmukh,Yun Chau Long,Theodore Moller,Heikki A. Koistinen,Kenneth Caidahl,Juleen R. Zierath,Anna Krook +7 more
TL;DR: In this article, the authors determined the direct effects of IL-6 on glucose transport and signal transduction in human skeletal muscle, and they found that IL exposure increased glucose transport by 1.3-fold (P < 0.05) and reduced phosphorylation of S6 ribosomal protein.
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Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene Expression
TL;DR: Evidence is provided that calcineurin-mediated skeletal muscle reprogramming induces the expression of several transcription regulators that coordinate changes in theexpression of genes for lipid and glucose metabolism, which in turn alters energy substrate utilization in skeletal muscle.