A
Alexandra A Gavidia
Researcher at Stanford University
Publications - 5
Citations - 68
Alexandra A Gavidia is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Biology. The author has an hindex of 2, co-authored 3 publications receiving 11 citations.
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Journal ArticleDOI
A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy.
Aviva Levitas,Emad Muhammad,Yuan Zhang,Isaac Perea Gil,Ricardo Serrano,Nashielli Diaz,Maram Arafat,Alexandra A Gavidia,Michael S. Kapiloff,Mark Mercola,Yoram Etzion,Ruti Parvari,Ioannis Karakikes +12 more
TL;DR: This study identified SPEG E1680K as a novel mutation associated with early onset DCM and provides evidence for its pathogenicity in vitro, providing a conceptual paradigm for establishing genotype-phenotype associations in DCM with autosomal recessive inheritance.
Journal ArticleDOI
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy.
Dries A.M. Feyen,Dries A.M. Feyen,Isaac Perea-Gil,Isaac Perea-Gil,Renee G.C. Maas,Magdalena Harakalova,Alexandra A Gavidia,Jennifer Arthur Ataam,Jennifer Arthur Ataam,Ting-Hsuan Wu,Aryan Vink,Jiayi Pei,Nirmal Vadgama,Nirmal Vadgama,Albert J. H. Suurmeijer,Wouter P. te Rijdt,Michelle Vu,Michelle Vu,Prashila L Amatya,Prashila L Amatya,Maricela Prado,Yuan Zhang,Logan Dunkenberger,Joost P.G. Sluijter,Karim Sallam,Karim Sallam,Folkert W. Asselbergs,Mark Mercola,Mark Mercola,Ioannis Karakikes,Ioannis Karakikes +30 more
TL;DR: In this paper, the loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopa and increased contractility in the heart.
Journal ArticleDOI
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
Isaac Perea-Gil,Timon Seeger,Arne A. N. Bruyneel,Vittavat Termglinchan,Emma Marie Monte,Esther W. Lim,Nirmal Vadgama,Takaaki Furihata,Alexandra A Gavidia,Jennifer Arthur Ataam,Nike Bharucha,Noel Martinez-Amador,Mohamed Ameen,Pooja Nair,Ricardo Serrano,Balpreet Kaur,Dries A. M. Feyen,Sebastian Diecke,Michael Snyder,Christian M. Metallo,Mark Mercola,Ioannis Karakikes +21 more
TL;DR: It is suggested that modulation of serine biosynthesis signalling may represent a novel genotype-agnostic therapeutic strategy for genetic DCM.
Journal ArticleDOI
Generation of AAVS1 integrated doxycycline-inducible CRISPR-Prime Editor human induced pluripotent stem cell line
TL;DR: In this paper, a doxycycline-inducible prime editor (PE2) was integrated into the AAVS1 genomic safe harbor locus to facilitate prime editing in human induced pluripotent stem cells (iPSCs).
Journal ArticleDOI
Generation of a dual edited human induced pluripotent stem cell Myl7-GFP reporter line with inducible CRISPRi/dCas9
Eyal Metzl-Raz,Nike Bharucha,Jennifer Arthur Ataam,Alexandra A Gavidia,William J. Greenleaf,Ioannis Karakikes +5 more
TL;DR: In this article , the authors presented an inducible CRISPRi platform enabling selection of iPSC-derived cardiomyocytes and reversible gene knockdown, which is critical for genetic screens.