J
Joost P.G. Sluijter
Researcher at Utrecht University
Publications - 241
Citations - 13201
Joost P.G. Sluijter is an academic researcher from Utrecht University. The author has contributed to research in topics: Progenitor cell & Heart failure. The author has an hindex of 53, co-authored 210 publications receiving 10469 citations. Previous affiliations of Joost P.G. Sluijter include University of Groningen & University Medical Center.
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Journal ArticleDOI
Correction: Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells
Ana Soares,Tania Martins-Marques,Teresa Ribeiro-Rodrigues,Joao Vasco Ferreira,Steve Catarino,Maria João Pinho,Mónica Zuzarte,Sandra I. Anjo,Bruno Manadas,Joost P.G. Sluijter,Paulo Pereira,Henrique Girão +11 more
TL;DR: It is shown that Connexin 43 (Cx43), the most widely expressed GJ protein, is present in exosomes in the form of hexameric channels and, more importantly, that exosomal Cx43 is able to modulate the interaction and transfer of information between exosome and acceptor cells.
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Inhibition of miR-25 improves cardiac contractility in the failing heart
Christine Wahlquist,Dongtak Jeong,Agustin Rojas-Muñoz,Changwon Kho,Ahyoung Lee,Shinichi Mitsuyama,Alain van Mil,Woo Jin Park,Joost P.G. Sluijter,Pieter A. Doevendans,Roger J. Hajjar,Mark Mercola +11 more
TL;DR: High-throughput functional screening of the human microRNAome reveals that increased expression of endogenous miR-25 contributes to declining cardiac function during heart failure and suggests that it might be targeted therapeutically to restore function.
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Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells.
Roberto Gaetani,P. A. F. M. Doevendans,Corina H.G. Metz,Jacqueline Alblas,Elisa Messina,Alessandro Giacomello,Joost P.G. Sluijter +6 more
TL;DR: This study evaluated the combination of TP, human cardiac-derived cardiomyocyte progenitor cells (hCMPCs) and biomaterials to obtain a construct with cardiogenic potential for in vitro use or in vivo application and showed that printing can be used for defined cell delivery, while retaining functional properties.
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Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction
Leo Timmers,Joost P.G. Sluijter,J. Karlijn van Keulen,Imo E. Hoefer,Marcel G.J. Nederhoff,Marie-José Goumans,Pieter A. Doevendans,Cees J. A. van Echteld,Jaap A. Joles,Paul H.A. Quax,Jan J. Piek,Gerard Pasterkamp,Dominique P.V. de Kleijn +12 more
TL;DR: Data provide direct evidence for a causal role of TLR4 in postinfarct maladaptive LV remodeling, probably via inflammatory cytokine production and matrix degradation and may therefore constitute a novel target in the treatment of ischemic heart failure.
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MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells
Joost P.G. Sluijter,Alain van Mil,Patrick van Vliet,Corina H.G. Metz,Jia Liu,Pieter A. Doevendans,Marie-José Goumans +6 more
TL;DR: By modulating miR-1 and -499 expression levels, human CMPC function can be altered and differentiation directed, thereby enhancing cardiomyogenic differentiation.