T
Timon Seeger
Researcher at Stanford University
Publications - 41
Citations - 2459
Timon Seeger is an academic researcher from Stanford University. The author has contributed to research in topics: Transplantation & Haematopoiesis. The author has an hindex of 19, co-authored 36 publications receiving 2105 citations. Previous affiliations of Timon Seeger include Cardiovascular Institute of the South & German Cancer Research Center.
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Journal ArticleDOI
MicroRNA-34a regulates cardiac ageing and function
Reinier A. Boon,Kazuma Iekushi,Stefanie Lechner,Timon Seeger,Ariane Fischer,Susanne Heydt,David Kaluza,Karine Tréguer,Guillaume Carmona,Angelika Bonauer,Anton J.G. Horrevoets,Nathalie Didier,Zenawit Girmatsion,Peter Biliczki,Joachim R. Ehrlich,Hugo A. Katus,Oliver Müller,Michael Potente,Michael Potente,Andreas M. Zeiher,Heiko Hermeking,Stefanie Dimmeler +21 more
TL;DR: Age-induced expression of miR-34a and inhibition of its target PNUTS is identified as a key mechanism that regulates cardiac contractile function during ageing and after acute myocardial infarction, by inducing DNA damage responses and telomere attrition.
Journal ArticleDOI
MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
Reinier A. Boon,Timon Seeger,Susanne Heydt,Ariane Fischer,Eduard Hergenreider,Anton J.G. Horrevoets,Manlio Vinciguerra,Nadia Rosenthal,Sergio Sciacca,Michele Pilato,Paula M. van Heijningen,Jeroen Essers,Ralf P. Brandes,Andreas M. Zeiher,Stefanie Dimmeler +14 more
TL;DR: In this paper, the authors identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies, including aneurysm formation.
Journal ArticleDOI
Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial
Hossein Ardeschir Ghofrani,Frank Reichenberger,Markus G. Kohstall,Eike H. Mrosek,Timon Seeger,Horst Olschewski,Werner Seeger,Friedrich Grimminger +7 more
TL;DR: In this article, the effects of sildenafil on exercise capacity under conditions of hypoxic pulmonary hypertension were investigated in a randomized, double-blind, placebo-controlled crossover study.
Journal Article
Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp
Hossein Ardeschir Ghofrani,Frank Reichenberger,Markus G. Kohstall,Eike H. Mrosek,Timon Seeger,Horst Olschewski,Werner Seeger,Friedrich Grimminger +7 more
TL;DR: This small study examined the influence of oral sildenafil on pulmonary hemodynamics and exercise tolerance during hypoxia-induced pulmonary hypertension in healthy volunteers who were not susceptible to high-altitude pulmonary edema.
Journal ArticleDOI
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy.
Jae Cheol Lee,Vittavat Termglinchan,Vittavat Termglinchan,Sebastian Diecke,Ilanit Itzhaki,Ilanit Itzhaki,Chi Keung Lam,Chi Keung Lam,Priyanka Garg,Priyanka Garg,Edward Lau,Edward Lau,Matthew Greenhaw,Timon Seeger,Timon Seeger,Haodi Wu,Haodi Wu,Joe Z. Zhang,Joe Z. Zhang,Xingqi Chen,Isaac Perea Gil,Isaac Perea Gil,Mohamed Ameen,Mohamed Ameen,Karim Sallam,Karim Sallam,June-Wha Rhee,June-Wha Rhee,Jared M. Churko,Jared M. Churko,Rinkal Chaudhary,Rinkal Chaudhary,Tony Chour,Tony Chour,Paul J. Wang,Michael Snyder,Michael Snyder,Howard Y. Chang,Howard Y. Chang,Ioannis Karakikes,Ioannis Karakikes,Joseph C. Wu,Joseph C. Wu +42 more
TL;DR: A disease model using cardiomyocytes derived from induced pluripotent stem cells of patients with mutated LMNA-related dilated cardiopathy reveals that the abnormal activation of the PDGF pathway is associated with the arrhythmic phenotypes of patients.