Tianyan Gao

TL;DR: PHLPP levels are markedly reduced in several colon cancer and glioblastoma cell lines that have elevated Akt phosphorylation, consistent with PHLPP terminating Akt signaling by directly dephosphorylating and inactivating Akt.

TL;DR: The data unveil a mechanism to selectively terminate Akt-signaling pathways through the differential inactivation of specific Akt isoforms by specific PHLPP isoforms.

TL;DR: The discovery of Y260 in α1 Na/K-ATPase as a Src-specific phosphorylation and binding site is discovered and it is suggested that the role of this regulation in control of Warburg effect and tumor growth may lead to Warburg phenotype in cancer.

TL;DR: The PKA-mediated regulation of L-type Ca2+ channels is critically dependent on a functional AKAP and phosphorylation of the alpha1C subunit at Ser1928, demonstrating that the events observed in the heterologous expression system reflect those occurring in the native system.

TL;DR: It is found that increased expression of mTOR, Raptor, and Rictor mRNA was noted with advanced stages of CRC, suggesting that mTOR signaling may be associated with CRC progression and metastasis, and provides the rationale for including mTOR kinase inhibitors, which inhibit both mTORC1 and m TORC2, as part of the therapeutic regimen for CRC patients.