A
Alexandra K. Bell
Researcher at University of Glasgow
Publications - 13
Citations - 1323
Alexandra K. Bell is an academic researcher from University of Glasgow. The author has contributed to research in topics: Breast cancer & Involution (medicine). The author has an hindex of 11, co-authored 13 publications receiving 1268 citations.
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Journal ArticleDOI
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Daniele Bergamaschi,Milena Gasco,Louise Hiller,Alexandra Sullivan,Nelofer Syed,Giuseppe Trigiante,Isik G. Yulug,Marco Merlano,Gianmauro Numico,Alberto Comino,Marlene Attard,Olivier Reelfs,Barry A. Gusterson,Alexandra K. Bell,Victoria J. Heath,Mahvash Tavassoli,Paul J. Farrell,Paul R. Smith,Xin Lu,Tim Crook +19 more
TL;DR: Polymorphism in p53 may influence individual responsiveness to cancer therapy, and clinical response following cisplatin-based chemo-radiotherapy for advanced head and neck cancer is influenced by this polymorphism, cancers expressing 72R mutants having lower response rates than those expressing 72P mutants.
Journal ArticleDOI
Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3
Torsten Stein,Joanna S. Morris,Claire R. Davies,Stephen J. Weber-Hall,Marie-Anne Duffy,Victoria J. Heath,Alexandra K. Bell,Roderick K. Ferrier,G. P. Sandilands,Barry A. Gusterson +9 more
TL;DR: Oligonucleotide microarrays are a useful tool for identifying genes that are involved in the complex developmental process of mammary glands involution, with an early acute-phase response that occurs in the mammary gland itself and resembles a wound healing process.
Journal Article
Epigenetic Inactivation of 14-3-3 σ in Oral Carcinoma Association with p16INK4a Silencing and Human Papillomavirus Negativity
Milena Gasco,Alexandra K. Bell,Victoria L. Heath,Alex Sullivan,Paul Smith,Louise Hiller,Isik G. Yulug,Gianmauro Numico,Marco Merlano,Paul J. Farrell,Mahvash Tavassoli,Barry A. Gusterson,Tim Crook +12 more
TL;DR: Results implicate coincident epigenetic abrogation of function in both sigma and p16(INK4a) in a subset of SCCs of the oral cavity that were more commonly detected in cancers with wild-type p53.
Journal ArticleDOI
Concomitant inactivation of p53 and Chk2 in breast cancer.
Alexandra Sullivan,Martin Yuille,Claire Repellin,Archana Reddy,Olivier Reelfs,Alexandra K. Bell,Barbara Dunne,Barry A. Gusterson,Peter Osin,Paul J. Farrell,Isik G. Yulug,Abigail Evans,Tayfun Ozcelik,Milena Gasco,Tim Crook +14 more
TL;DR: The results nevertheless reveal that concomitant loss of function in Chk2 (via down-regulation of expression) and p53 (via mutation) occurs in a proportion of sporadic cases, and it is shown that germ-line mutations in ChK2 are unlikely to account for a significant proportion of non BRCA1-, non B RCA2-associated hereditary breast cancers.
Journal ArticleDOI
Loss of Reelin Expression in Breast Cancer Is Epigenetically Controlled and Associated with Poor Prognosis
Torsten Stein,Emilio Cosimo,Xinzi Yu,Paul R. Smith,Ronald Simon,Lorna Cottrell,Marie Anne Pringle,Alexandra K. Bell,Laura Lattanzio,Guido Sauter,Cristiana Lo Nigro,Tim Crook,Laura M. Machesky,Barry A. Gusterson +13 more
TL;DR: It is concluded that reelin may play an important role in controlling invasiveness and metastatic potential of breast cancer cells and that its expression is controlled by promoter methylation.