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Xin Lu
Researcher at Ludwig Institute for Cancer Research
Publications - 169
Citations - 18269
Xin Lu is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Cancer & Transactivation. The author has an hindex of 57, co-authored 159 publications receiving 16873 citations. Previous affiliations of Xin Lu include National Institute for Health Research & Kunming Institute of Zoology.
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Journal ArticleDOI
Live or let die: the cell's response to p53
Karen H. Vousden,Xin Lu +1 more
TL;DR: Understanding the complex mechanisms that regulate whether or not a cell dies in response to p53 will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
Lorenzo Galluzzi,Ilio Vitale,Ilio Vitale,Ilio Vitale,John M. Abrams,Emad S. Alnemri,Eric H. Baehrecke,Mikhail V. Blagosklonny,Ted M. Dawson,Valina L. Dawson,Wafik S. El-Deiry,Simone Fulda,Eyal Gottlieb,Douglas R. Green,Michael O. Hengartner,Oliver Kepp,Oliver Kepp,Oliver Kepp,Richard A. Knight,Sharad Kumar,Sharad Kumar,Stuart A. Lipton,Xin Lu,Frank Madeo,Walter Malorni,Patrick Mehlen,Gabriel Núñez,Marcus E. Peter,Mauro Piacentini,David C. Rubinsztein,Yufang Shi,Hans-Uwe Simon,Peter Vandenabeele,Eileen White,Junying Yuan,Boris Zhivotovsky,Gerry Melino,Gerry Melino,Guido Kroemer +38 more
TL;DR: A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe.
Journal ArticleDOI
Differential induction of transcriptionally active p53 following UV or ionizing radiation : defects in chromosome instability syndromes ?
Xin Lu,David P. Lane +1 more
TL;DR: The authors find no substantive defect in the p53 response of cells from ataxia telangiectasia or xeroderma pigmentosum complementation group A patients, and 2 out of 11 primary cultures from Bloom's patients showed a complete absence of p53 accumulation following UV irradiation or SV40 infection and a grossly delayed and aberrant response following X-ray.
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ASPP proteins specifically stimulate the apoptotic function of p53.
Yardena Samuels-Lev,Daniel J. O'Connor,Daniele Bergamaschi,Giuseppe Trigiante,Jung-Kuang Hsieh,Shan Zhong,Isabelle Campargue,Louie Naumovski,Tim Crook,Xin Lu +9 more
TL;DR: The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53, therefore, ASPP regulate the tumor suppression function of p53 in vivo.
Journal ArticleDOI
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Daniele Bergamaschi,Milena Gasco,Louise Hiller,Alexandra Sullivan,Nelofer Syed,Giuseppe Trigiante,Isik G. Yulug,Marco Merlano,Gianmauro Numico,Alberto Comino,Marlene Attard,Olivier Reelfs,Barry A. Gusterson,Alexandra K. Bell,Victoria J. Heath,Mahvash Tavassoli,Paul J. Farrell,Paul R. Smith,Xin Lu,Tim Crook +19 more
TL;DR: Polymorphism in p53 may influence individual responsiveness to cancer therapy, and clinical response following cisplatin-based chemo-radiotherapy for advanced head and neck cancer is influenced by this polymorphism, cancers expressing 72R mutants having lower response rates than those expressing 72P mutants.