A
Alexandra Lorenz
Researcher at Technical University of Berlin
Publications - 32
Citations - 1632
Alexandra Lorenz is an academic researcher from Technical University of Berlin. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 13, co-authored 32 publications receiving 1333 citations. Previous affiliations of Alexandra Lorenz include Leibniz Association & Charité.
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Journal ArticleDOI
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
Ilka Maschmeyer,Alexandra Lorenz,Katharina Schimek,Tobias Hasenberg,Anja Patricia Ramme,Juliane Hübner,Marcus Lindner,Christopher Drewell,Sophie Bauer,Alexander Thomas,Naomia Sisoli Sambo,Frank Sonntag,Roland Lauster,Uwe Marx +13 more
TL;DR: This study is the first approach to establish a system for in vitro microfluidic ADME profiling and repeated dose systemic toxicity testing of drug candidates over 28 days in co-culture, and assures near to physiological fluid-to-tissue ratios.
Journal ArticleDOI
Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro.
Ilka Maschmeyer,Tobias Hasenberg,Annika Jaenicke,Marcus Lindner,Alexandra Lorenz,Julie Zech,Leif-Alexander Garbe,Frank Sonntag,Patrick Hayden,Seyoum Ayehunie,Roland Lauster,Uwe Marx,Eva-Maria Materne +12 more
TL;DR: A reproducible homeostatic long-term co-culture of human liver equivalents with either a reconstructed human intestinal barrier model or a human skin biopsy applying a microphysiological system is reported on.
Journal ArticleDOI
Integrating biological vasculature into a multi-organ-chip microsystem
Katharina Schimek,Mathias Busek,Mathias Busek,Sven Brincker,Benjamin Groth,Silke Hoffmann,Roland Lauster,Gerd Lindner,Alexandra Lorenz,Ulrike Menzel,Frank Sonntag,Heike Walles,Uwe Marx,Reyk Horland +13 more
TL;DR: An in-depth microscopic analysis revealed the fine-tuned adjustment of endothelial cell behaviour to local shear stresses along the microvasculature of the chip-based transport system established at minute but standardized microsystem scale.
Journal ArticleDOI
T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies
Constanze Hess,André Winkler,Alexandra Lorenz,Vivien Holecska,Véronique Blanchard,Susanne Eiglmeier,Anna Lena Schoen,Anna Lena Schoen,Josephine Bitterling,Alexander D. Stoehr,Dominique Petzold,Dominique Petzold,Tim Schommartz,Maria M.M. Mertes,Carolin T. Schoen,Benjamin Tiburzy,Anne Herrmann,Jörg Köhl,Jörg Köhl,Rudolf A. Manz,Michael P. Madaio,Markus Berger,Hedda Wardemann,Marc Ehlers +23 more
TL;DR: Findings suggest an immune regulatory function forTI immune responses through the generation of immunosuppressive sialylated IgGs and may provide insight on the role of TI immune responses during infection, vaccination, and autoimmunity.
Journal ArticleDOI
Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs
Carolin M. Oefner,André Winkler,Constanze Hess,Alexandra Lorenz,Vivien Holecska,Melanie Huxdorf,Tim Schommartz,Dominique Petzold,Dominique Petzold,Josephine Bitterling,Anna Lena Schoen,Alexander D. Stoehr,Dana Vu Van,Dana Vu Van,Yasemin Darcan-Nikolaisen,Véronique Blanchard,Inken Schmudde,Yves Laumonnier,Heike A. Ströver,Ahmed N. Hegazy,Susanne Eiglmeier,Carolin T. Schoen,Maria M.M. Mertes,Christoph Loddenkemper,Christoph Loddenkemper,Max Löhning,Peter König,Arnd Petersen,Elke O. Luger,Mattias Collin,Jörg Köhl,Andreas Hutloff,Andreas Hutloff,Eckard Hamelmann,Eckard Hamelmann,Markus Berger,Hedda Wardemann,Marc Ehlers,Marc Ehlers +38 more
TL;DR: The data show a novel antigen-specific immunoregulatory mechanism mediated by anti-inflammatory sialylated IgGs that are formed on TD tolerance induction, which might help to develop novel antibody-specific therapies for the treatment of allergy and autoimmunity.