M
Max Löhning
Researcher at Charité
Publications - 88
Citations - 9343
Max Löhning is an academic researcher from Charité. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 41, co-authored 72 publications receiving 8560 citations. Previous affiliations of Max Löhning include Leibniz Association & University of Zurich.
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Journal ArticleDOI
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Chris Schiering,Thomas Krausgruber,Agnieszka Chomka,Anja Fröhlich,Krista Adelmann,Elizabeth A. Wohlfert,Johanna Pott,Thibault Griseri,Julia Bollrath,Ahmed N. Hegazy,Oliver J. Harrison,Benjamin M. J. Owens,Max Löhning,Yasmine Belkaid,Padraic G. Fallon,Fiona Powrie +15 more
TL;DR: It is shown in mice that the IL-33 receptor ST2 is preferentially expressed on colonic Treg cells, where it promotes Treg function and adaptation to the inflammatory environment, and suggests that the balance between IL- 33 and IL-23 may be a key controller of intestinal immune responses.
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P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
Frank Austrup,Dietmar Vestweber,Eric Borges,Max Löhning,Rolf Bräuer,Udo Herz,Harald Renz,Rupert Hallmann,Alexander Scheffold,Andreas Radbruch,Alf Hamann +10 more
TL;DR: It is shown that Th1 cells, but not Th2 cells, are able to bind to P- selectin and E-selectin, indicating that selective recruitment is an additional level of regulation for both effector function profile and character of a local immune response.
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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
Wenjun Ouyang,Max Löhning,Zhiguang Gao,Mario Assenmacher,Sheila Ranganath,Andreas Radbruch,Kenneth M. Murphy +6 more
TL;DR: Introducing GATA-3 into Stat6-deficient T cells completely restored Th2 development, inducing c-Maf, Th2-specific DNase I hypersensitive sites in the IL-4 locus, and Th2 cytokine expression and creating a feedback pathway stabilizing Th2 commitment.
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T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
Max Löhning,Arne Stroehmann,Anthony J. Coyle,Jane L. Grogan,Steven Lin,Jose-Carlos Gutierrez-Ramos,Douglas F. Levinson,Andreas Radbruch,Thomas Kamradt +8 more
TL;DR: Potential target genes preferentially expressed in Th2 cells, expressing interleukin (IL)-4, IL-5, and/or IL-10, but not interferon-gamma are identified and one such gene, T1/ST2, is expressed stably on both Th2 clones and Th2-polarized cells activated in vivo or in vitro.
Journal ArticleDOI
Eosinophils are required for the maintenance of plasma cells in the bone marrow
Van Trung Chu,Anja Fröhlich,Gudrun Steinhauser,Tobias Scheel,Toralf Roch,Simon Fillatreau,James J. Lee,Max Löhning,Claudia Berek +8 more
TL;DR: It is demonstrated that bone marrow eosinophils localized together with plasma cells and were the key providers of plasma cell survival factors and depletion of eosInophils induced apoptosis in long-lived bone marrow plasma cells.