Roland Lauster

TL;DR: This study is the first approach to establish a system for in vitro microfluidic ADME profiling and repeated dose systemic toxicity testing of drug candidates over 28 days in co-culture, and assures near to physiological fluid-to-tissue ratios.

TL;DR: A multi-organ-chip capable of maintaining 3D tissues derived from cell lines, primary cells and biopsies of various human organs is presented, providing a potential new tool for systemic substance testing.

TL;DR: As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent down regulation of the 75 kD neurotrophin receptor in the developing hair follicle.

TL;DR: It is shown that the major green tea constituent, (−)-epigallocatechin-3-gallate (EGCG), dramatically suppresses EAE induced by proteolipid protein 139–151 and reduced clinical severity when given at initiation or after the onset of EAE by both limiting brain inflammation and reducing neuronal damage.

TL;DR: Modulation of BMP4 signaling by noggin is essential for hair growth phase induction in postnatal skin and that the hair growth‐inducing effect of nogsgin is mediated, at least in part, by Shh.