Gerd Lindner

TL;DR: As a crucial mesenchymal signal that stimulates hair-follicle induction, Noggin operates through antagonistic interactions with BMP-4, which result in upregulation of the transcription factor Lef-1 and the cell-adhesion molecule NCAM, as well as through BMP4-independent down regulation of the 75 kD neurotrophin receptor in the developing hair follicle.

TL;DR: Select receptors of the tumor necrosis factor/nerve growth factor family and members of the Bcl-2 family may also play a key role in the control of follicular keratinocyte apoptosis in situ.

TL;DR: IL-15 is a potent, general inhibitor of apoptosis in vitro and in vivo with intriguing therapeutic potential and is completely protected from lethal hepatic failure.

TL;DR: Data strongly support that TGF‐β1 ranks among the elusive endogenous regulators of catagen induction in vivo, possibly via the inhibition of keratinocyte proliferation and induction of apoptosis.

TL;DR: A dynamically perfused chip-based bioreactor platform capable of applying variable mechanical shear stress and extending culture periods is described, leading to improvements of culture conditions for integrated in vitro skin models, ex vivo skin organ cultures and biopsies of single hair follicular units.