F
Frank Sonntag
Researcher at Fraunhofer Society
Publications - 85
Citations - 2607
Frank Sonntag is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Surface plasmon resonance & Photonic crystal. The author has an hindex of 18, co-authored 79 publications receiving 2198 citations.
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A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
Ilka Maschmeyer,Alexandra Lorenz,Katharina Schimek,Tobias Hasenberg,Anja Patricia Ramme,Juliane Hübner,Marcus Lindner,Christopher Drewell,Sophie Bauer,Alexander Thomas,Naomia Sisoli Sambo,Frank Sonntag,Roland Lauster,Uwe Marx +13 more
TL;DR: This study is the first approach to establish a system for in vitro microfluidic ADME profiling and repeated dose systemic toxicity testing of drug candidates over 28 days in co-culture, and assures near to physiological fluid-to-tissue ratios.
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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
Ilka Wagner,Eva-Maria Materne,Sven Brincker,Ute Süßbier,Caroline Frädrich,Mathias Busek,Mathias Busek,Frank Sonntag,D. A. Sakharov,E. V. Trushkin,Alexander G. Tonevitsky,Roland Lauster,Uwe Marx +12 more
TL;DR: A multi-organ-chip capable of maintaining 3D tissues derived from cell lines, primary cells and biopsies of various human organs is presented, providing a potential new tool for systemic substance testing.
Journal ArticleDOI
Direct comparison of the performance of Bloch surface wave and surface plasmon polariton sensors
Alberto Sinibaldi,Norbert Danz,Emiliano Descrovi,Peter Munzert,Ulrike Schulz,Frank Sonntag,Lorenzo Dominici,Francesco Michelotti +7 more
TL;DR: In this paper, a direct experimental comparison of the sensitivity and figure of merit of biosensors based either on surface plasmon polaritons on metal layers or on Bloch surface waves on one dimensional photonic crystals was conducted.
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Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro.
Ilka Maschmeyer,Tobias Hasenberg,Annika Jaenicke,Marcus Lindner,Alexandra Lorenz,Julie Zech,Leif-Alexander Garbe,Frank Sonntag,Patrick Hayden,Seyoum Ayehunie,Roland Lauster,Uwe Marx,Eva-Maria Materne +12 more
TL;DR: A reproducible homeostatic long-term co-culture of human liver equivalents with either a reconstructed human intestinal barrier model or a human skin biopsy applying a microphysiological system is reported on.
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Integrating biological vasculature into a multi-organ-chip microsystem
Katharina Schimek,Mathias Busek,Mathias Busek,Sven Brincker,Benjamin Groth,Silke Hoffmann,Roland Lauster,Gerd Lindner,Alexandra Lorenz,Ulrike Menzel,Frank Sonntag,Heike Walles,Uwe Marx,Reyk Horland +13 more
TL;DR: An in-depth microscopic analysis revealed the fine-tuned adjustment of endothelial cell behaviour to local shear stresses along the microvasculature of the chip-based transport system established at minute but standardized microsystem scale.