Alexandra M. Nanzer

TL;DR: These data identify immunologic pathways that likely underpin the beneficial clinical effects of calcitriol in patients with SR asthma by directing the SR cytokine profile toward a more SS immune phenotype, suggesting strategies for identifying vitamin D responder immunophenotypes.

TL;DR: 1,25(OH)2D3 inhibits TH17 cytokine production in all patients studied, irrespective of their clinical responsiveness to steroids, identifying novel steroid-enhancing properties of vitamin D in asthmatic patients.

TL;DR: The role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma are discussed.

TL;DR: Ghrelin has been shown to have anti-proliferative effects on breast, lung and thyroid cell lines as discussed by the authors, and the effect of ghrelin on the rat pituitary cell line GH3 was studied using immunoblotting and inhibitors of the extracellular signal-regulated kinase 1 and 2 (ERK 1/2), protein kinase C (PKC) and tyrosine phosphatase pathways.

TL;DR: In a large real-world SEA cohort, benralizumab led to significant improvements in all clinical outcome measures and the optimal regression model of super-responders versus other responders included baseline characteristics associated with a strongly eosinophilic phenotype and less severe disease.