S
Sarah Dimeloe
Researcher at University of Birmingham
Publications - 42
Citations - 2959
Sarah Dimeloe is an academic researcher from University of Birmingham. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 19, co-authored 35 publications receiving 2060 citations. Previous affiliations of Sarah Dimeloe include University of Basel & University Hospital of Basel.
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Journal ArticleDOI
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
Daniela S. Thommen,Daniela S. Thommen,Viktor H. Koelzer,Petra Herzig,Andreas Roller,Marcel P. Trefny,Sarah Dimeloe,Anna Kiialainen,Jonathan C Hanhart,Catherine Schill,Christoph Hess,Spasenija Savic Prince,Mark Wiese,Didier Lardinois,Ping-Chih Ho,Christian Klein,Vaios Karanikas,Kirsten D. Mertz,Ton N. Schumacher,Alfred Zippelius +19 more
TL;DR: The characterization of a distinct state of tumor-reactive, PD-1-bright lymphocytes in human cancer, which only partially resembles that seen in chronic infection, provides potential avenues for therapeutic intervention.
Journal ArticleDOI
Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
Patrick Gubser,Glenn R. Bantug,Leyla Razik,Marco Fischer,Sarah Dimeloe,Gideon Hoenger,Bojana Durovic,Annaïse Jauch,Christoph Hess +8 more
TL;DR: CD8+ memory T cells have an Akt-dependent 'imprinted' glycolytic potential that is required for efficient immediate-early IFN-γ recall responses.
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Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function.
Maria L. Balmer,Eric H. Ma,Glenn R. Bantug,Jasmin Grählert,Simona P. Pfister,Timo Glatter,Annaïse Jauch,Sarah Dimeloe,Emma Slack,Philippe Dehio,Magdalena A. Krzyzaniak,Carolyn G. King,Anne-Valérie Burgener,Marco Fischer,Leyla Develioglu,Réka Belle,Mike Recher,Weldy V. Bonilla,Andrew J. Macpherson,Siegfried Hapfelmeier,Russell G. Jones,Christoph Hess +21 more
TL;DR: The results demonstrate that increased systemic acetate concentrations are functionally integrated by CD8(+) T cells and translate into increased glycolytic and functional capacity, and the immune system thus directly relates systemic metabolism with immune alertness.
Journal ArticleDOI
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
Martin Kolev,Sarah Dimeloe,Gaelle Le Friec,Alexander A. Navarini,Giuseppina Arbore,Giovanni A M Povoleri,Giovanni A M Povoleri,Marco Fischer,Réka Belle,Jordan Loeliger,Leyla Develioglu,Glenn R. Bantug,Julie Watson,Lionel Couzi,Behdad Afzali,Behdad Afzali,Behdad Afzali,Paul Lavender,Christoph Hess,Claudia Kemper +19 more
TL;DR: It is found that in activated human T cells, autocrine stimulation of the complement receptor CD46, and specifically its intracellular domain CYT-1, was required for induction of the amino acid (AA) transporter LAT1 and enhanced expression of the glucose transporter GLUT1.
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The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells
Zoe Urry,Emma S. Chambers,Emmanuel Xystrakis,Sarah Dimeloe,David F. Richards,Leona Gabryšová,Jillian R. Christensen,Atul Gupta,Sejal Saglani,Andrew Bush,Anne O'Garra,Zarin Brown,Catherine M. Hawrylowicz +12 more
TL;DR: Evidence is provided that 1α25VitD3, over a broad concentration range, will be effective in enhancing the frequency of Treg cells, and a positive in vivo correlation between vitamin D status and CD4+Foxp3+ T cells in the airways was observed in a severe pediatric asthma cohort, supporting the in vitro observations.