J
Jorge Gallego
Researcher at French Institute of Health and Medical Research
Publications - 132
Citations - 4871
Jorge Gallego is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Congenital central hypoventilation syndrome & Hypercapnia. The author has an hindex of 38, co-authored 125 publications receiving 4538 citations. Previous affiliations of Jorge Gallego include University of Paris & Paris Diderot University.
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Journal ArticleDOI
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
Stéphane Jamain,Konstantin Radyushkin,Kurt Hammerschmidt,Sylvie Granon,Susann Boretius,Frederique Varoqueaux,Nelina Ramanantsoa,Jorge Gallego,Anja Ronnenberg,Dorina Winter,Jens Frahm,Julia Fischer,Thomas Bourgeron,Hannelore Ehrenreich,Nils Brose +14 more
TL;DR: It is reported that mice with a loss-of-function mutation in the murine NLGN4 ortholog Nlgn4, which encodes the synaptic cell adhesion protein Neuroligin-4, exhibit highly selective deficits in reciprocal social interactions and communication that are reminiscent of ASCs in humans.
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Systemic inflammation disrupts the developmental program of white matter
Géraldine Favrais,Yohan van de Looij,Bobbi Fleiss,Nelina Ramanantsoa,Nelina Ramanantsoa,Philippe Bonnin,Gisela Stoltenburg-Didinger,Adrien Lacaud,Elie Saliba,Olaf Dammann,Olaf Dammann,Olaf Dammann,Jorge Gallego,Jorge Gallego,Stéphane Sizonenko,Henrik Hagberg,Henrik Hagberg,Vincent Lelievre,Pierre Gressens +18 more
TL;DR: The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development.
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Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways
Stéphane Dauger,Alexandre Pattyn,Frédéric Lofaso,Claude Gaultier,Christo Goridis,Jorge Gallego,Jean-François Brunet +6 more
TL;DR: It is reported that the afferent relays of visceral reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose).
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A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
Véronique Dubreuil,Nelina Ramanantsoa,Delphine Trochet,Vanessa Vaubourg,Jeanne Amiel,Jorge Gallego,Jean-François Brunet,Christo Goridis +7 more
TL;DR: It is shown that mice bearing a mutation in Phox2b that causes congenital central hypoventilation syndrome in humans breathe irregularly, do not respond to an increase in CO2, and die soon after birth from central apnea.
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VGLUT3 (Vesicular Glutamate Transporter Type 3) Contribution to the Regulation of Serotonergic Transmission and Anxiety
Bénédicte Amilhon,Eve M. Lepicard,Thibault Renoir,Raymond Mongeau,Daniela Popa,Odile Poirel,Stéphanie Miot,Christelle Gras,Alain M. Gardier,Jorge Gallego,Michel Hamon,Laurence Lanfumey,Bruno Gasnier,Bruno Giros,Salah El Mestikawy +14 more
TL;DR: It is found that deletion of VGLUT3 increased several anxiety-related behaviors in adult and in newborn mice as early as 8 d after birth and the results suggest that the loss of V GLUT3 expression leads to anxiety-associated behaviors and should be considered as a potential new target for the treatment of this disorder.